{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:57Z","timestamp":1787014137801,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Parkinson's disease (PD) and vitamin D share a unique link as vitamin D deficiency (VDD) prevails in PD. Thus, an in\u2010depth understanding of vitamin D biology in PD might be crucial for therapeutic strategies emphasising vitamin D. Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D\u2010associated genes in PD, like\n                    <jats:italic>VDR<\/jats:italic>\n                    (vitamin D receptor) or\n                    <jats:italic>GC<\/jats:italic>\n                    (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g.,\n                    <jats:italic>CYP2R1<\/jats:italic>\n                    and\n                    <jats:italic>CYP27A1<\/jats:italic>\n                    ) in PD. Literature review of single nucleotide polymorphisms (SNPs) related to vitamin D levels [\n                    <jats:italic>GC<\/jats:italic>\n                    (GC1\u2010rs7041 and GC2\u2010rs4588),\n                    <jats:italic>CYP2R1<\/jats:italic>\n                    , CYP24A1 and CYP27B1] and vitamin D function [\n                    <jats:italic>VDR<\/jats:italic>\n                    (FokI \u2010 rs2228570 and rs10735810; ApaI \u2010 rs7976091, rs7975232BsmI and rs1544410; and TaqI \u2010 rs731236)] was conducted to explore their relationship with PD severity globally.\n                    <jats:italic>VDR<\/jats:italic>\n                    \u2010FokI polymorphism was reported to be significantly associated with PD in Hungarian, Chinese and Japanese populations, whereas\n                    <jats:italic>VDR<\/jats:italic>\n                    \u2010ApaI polymorphism was found to affect PD in the Iranian population. However,\n                    <jats:italic>VDR<\/jats:italic>\n                    \u2010TaqI and BsmI polymorphisms had no significant association with PD severity. Conversely,\n                    <jats:italic>GC1<\/jats:italic>\n                    polymorphisms reportedly affected vitamin D levels without influencing the disease severity.\n                    <jats:italic>CYP2R1<\/jats:italic>\n                    (excluding rs1993116) was also reportedly linked to clinical manifestations of PD. Genetic polymorphisms might cause VDD despite enough sunlight exposure and vitamin D\u2010rich food intake, enhancing inflammation, there by influencing PD pathophysiology. Knowledge of the polymorphisms associated with VDD appears promising for developing precision vitamin D\u2010dosing therapeutic strategies against PD.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16098","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T04:30:04Z","timestamp":1690173004000},"page":"3362-3377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D deficiency and genetic polymorphisms of vitamin D\u2010associated genes in Parkinson's disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Randrita","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Physiology, Surendranath College University of Calcutta  Kolkata India"},{"name":"Institute of Neurosciences  Kolkata India"},{"name":"Department of Physiology University of Calcutta  Kolkata 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