{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:59Z","timestamp":1787014139833,"version":"build-2736575974"},"reference-count":77,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["110\u20102629\u2010H\u2010004\u2010001"],"award-info":[{"award-number":["110\u20102629\u2010H\u2010004\u2010001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["111\u20102811\u2010H\u2010004\u2010004"],"award-info":[{"award-number":["111\u20102811\u2010H\u2010004\u2010004"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Numerous empirical studies have reported that males and females perform equally well in mathematical achievement. However, still to date, very limited is understood about the brain response profiles that are particularly characteristic of males and females when solving mathematical problems. The present study aimed to tackle this issue by manipulating arithmetic problem size to investigate functional significance using functional magnetic resonance imaging (fMRI) in young adults. Participants were instructed to complete two runs of simple calculation tasks with either large or small problem sizes. Behavioural results suggested that the performance did not differ between females and males. Neuroimaging data revealed that sex\/gender\u2010related patterns of problem size effect were found in the brain regions that are conventionally associated with arithmetic, including the left middle frontal gyrus (MFG), left intraparietal sulcus (IPS) and insula. Specifically, females demonstrated substantial brain responses of problem size effect in these regions, whereas males showed marginal effects. Moreover, the machine learning method implemented over the brain signal levels within these regions demonstrated that sex\/gender is discriminable. These results showed sex\/gender effects in the activating patterns varying as a function of the distinct math problem size, even in a simple calculation task. Accordingly, our findings suggested that females and males use two complementary brain resources to achieve equally successful performance levels and highlight the pivotal role of neuroimaging facilities in uncovering neural mechanisms that may not be behaviourally salient.<\/jats:p>","DOI":"10.1111\/ejn.16100","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T21:24:36Z","timestamp":1689801876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arithmetic problem size modulates brain activations in females but not in males"],"prefix":"10.1111","author":[{"given":"Nai\u2010Feng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychology National Chengchi University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-1396","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychology National Chengchi University  Taipei Taiwan"},{"name":"Research Center for Mind, Brain and Learning National Chengchi University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2334"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1214\/09-SS054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.009"},{"key":"e_1_2_9_6_1","first-page":"315","volume-title":"Handbook of mathematical cognition","author":"Ashcraft M.","year":"2005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.130.2.224"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03194059"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2012.04.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2007.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.136.2.256"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01404"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.130.2.299"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0023864"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/ceps.2000.1059"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-0663.89.2.318"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.01488"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2775"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24502"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.053"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.07.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00246"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.11.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.037"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290244000239"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-8-33"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11858-011-0309-6"},{"key":"e_1_2_9_29_1","volume-title":"Manual for kit of factor\u2010referenced cognitive tests","author":"Ekstrom R. 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