{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:45:50Z","timestamp":1792611950248,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been suggested that consciousness is closely related to the complexity of the brain. The perturbational complexity index (PCI) has been used in humans and rodents to distinguish conscious from unconscious states based on the global cortical responses (recorded by electroencephalography, EEG) to local cortical stimulation (CS). However, it is unclear how different cortical layers respond to CS and contribute to the resulting intra\u2010 and inter\u2010areal cortical connectivity and PCI. A detailed investigation of the local dynamics is needed to understand the basis for PCI. We hypothesized that the complexity level of global cortical responses (PCI) correlates with layer\u2010specific activity and connectivity. We tested this idea by measuring global cortical dynamics and layer\u2010specific activity in the somatosensory cortex (S1) of mice, combining cortical electrical stimulation in deep motor cortex, global electrocorticography (ECoG) and local laminar recordings from layers 1\u20136 in S1, during wakefulness and general anaesthesia (sevoflurane). We found that the transition from wake to sevoflurane anaesthesia correlated with a drop in both the global and local PCI (PCI<jats:sup>st<\/jats:sup>) values (complexity). This was accompanied by a local decrease in neural firing rate, spike\u2010field coherence and long\u2010range functional connectivity specific to deep layers (L5, L6). Our results suggest that deep cortical layers are mechanistically important for changes in PCI and thereby for changes in the state of consciousness.<\/jats:p>","DOI":"10.1111\/ejn.16108","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:04:06Z","timestamp":1692565446000},"page":"752-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Laminar evoked responses in mouse somatosensory cortex suggest a special role for deep layers in cortical complexity"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-8652","authenticated-orcid":false,"given":"Christoph","family":"H\u00f6nigsperger","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08935"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2021.02.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0343-20.2021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nc\/niac004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272215"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2020.07.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1837-20.2021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60824"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01472-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.03.032"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.021"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021261"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006294"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106186"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84630.3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9609.001.0001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111453"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.07.015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.05.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx122"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.034"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36816-z"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200110000-00026"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.06.078"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015910790909502"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117566"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1716-z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3917"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.390"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00101"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-17-06347.2000"},{"key":"e_1_2_11_34_1","first-page":"131","volume-title":"Handbook of clinical neurology","author":"Jones B. 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