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Thus, the present study examined the association between limbic volume and thickness measures and acute cortisol responses to the psychosocial stress paradigm Scan\n                    <jats:italic>STRESS<\/jats:italic>\n                    . Using Permutation Analysis of Linear Models controlling for sex, age and total brain volume, the associations between (sex\u2010specific) cortisol increases and human connectome project style anatomical variables of limbic structures (i.e. volume and thickness) were investigated in 66 healthy and young (18\u201333\u2009years) subjects (35 men, 31 women taking oral contraceptives). In addition, exploratory (sex\u2010specific) bivariate correlations between cortisol increases and structural measures were conducted. The present data provide interesting new insights into the involvement of striato\u2010limbic structures in psychosocial stress processing, suggesting that acute cortisol stress responses are also associated with mere structural measures of the human brain. Thus, our preliminary findings suggest that not only situation\u2010 and context\u2010dependent reactions of the limbic system (i.e. blood oxygenation level\u2010dependent reactions) are related to acute (sex\u2010specific) cortisol stress responses but also basal and somewhat more constant structural measures. Our study hereby paves the way for further analyses in this context and highlights the relevance of the topic.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16161","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:20:35Z","timestamp":1697052035000},"page":"3962-3980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between cortisol stress responses and limbic volume and thickness in young adults: An exploratory study"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3397-1351","authenticated-orcid":false,"given":"Gina\u2010Isabelle","family":"Henze","sequence":"first","affiliation":[{"name":"Institute of Psychology University of Regensburg  Regensburg Germany"},{"name":"Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of 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