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These pathological consequences lead to short\u2010 and long\u2010term neurobehavioural deficits. Till now there is no specific treatment that directly improves SAE and its associated behavioural impairments. In this review, we discuss the underlying mechanisms of sepsis\u2010induced brain injury with a focus on the latest progress regarding neuroprotective effects of SIRT1 (silent mating type information regulation\u20102 homologue\u20101). SIRT1 is an NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent class III protein deacetylase. It is able to modulate multiple downstream signals (including NF\u2010\u03baB, HMGB, AMPK, PGC1\u03b1 and FoxO), which are involved in the development of SAE by its deacetylation activity. There are multiple recent studies showing the neuroprotective effects of SIRT1 in neuroinflammation related diseases. The proposed neuroprotective action of SIRT1 is meant to bring a promising therapeutic strategy for managing SAE and ameliorating its related behavioural deficits.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16167","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:53:52Z","timestamp":1697406832000},"page":"4211-4235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of SIRT1 in sepsis\u2010induced encephalopathy: Molecular targets for future therapies"],"prefix":"10.1111","volume":"58","author":[{"given":"Alaa H.","family":"Shehata","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa F.","family":"Anter","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of 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