{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:47Z","timestamp":1772160227330,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Duchenne muscular dystrophy (DMD) is a severe progressive neuromuscular disorder that causes cardiac and respiratory failure. Patients with DMD have tachycardia and autonomic nervous dysfunction at a young age, which can potentially worsen cardiorespiratory function. Therefore, we hypothesised that plasticity occurs in neurons of the cardiorespiratory brainstem nucleus (nucleus tractus solitarius [NTS]) due to DMD, thus affecting neuronal regulation because afferent information from cardiorespiratory organs changes with disease progression. Patch\u2010clamp experiments were performed on second\u2010order NTS neurons from\n                    <jats:italic>Dmd<\/jats:italic>\n                    \u2010mutated (\n                    <jats:italic>D<\/jats:italic>\n                    m) rats that showed no functional dystrophin protein expression, as confirmed by immunohistochemistry. NTS neurons are classified into two electrophysiological phenotypes: one showing a delayed onset of spiking from hyperpolarised membrane potentials, namely, delayed\u2010onset spiking (DS)\u2010type neurons, and the other showing a rapid onset, namely, rapid\u2010onset spiking\u2010type neurons. Neuroplasticity mainly occurs in DS\u2010type neurons in Dm rats and is characterised by blunted neuronal excitability accompanied by reduced outward currents and a facilitatory effect on synaptic transmission, that is, an increased frequency of spontaneous and miniature excitatory postsynaptic currents (EPSCs) without changes in the amplitude and an increased amplitude of tractus solitarius\u2010evoked EPSCs without changes in the paired\u2010pulse ratio. Although we cannot rule out the possibility that the neuroplastic changes observed in\n                    <jats:italic>D<\/jats:italic>\n                    m rats were caused by dystrophin deficiency in the neurons themselves, the plasticity could be caused by cardiorespiratory deterioration and\/or adaptation in DMD patients.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16179","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T04:43:35Z","timestamp":1699332215000},"page":"4282-4297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene\u2010mutated rats"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1204-9683","authenticated-orcid":false,"given":"Akitoshi","family":"Chikamoto","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Tochinai","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-4667","authenticated-orcid":false,"given":"Shin\u2010ichi","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4598-14.2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00279.2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.12.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2654-12.2012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2004000400012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-08230.2002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01523.2001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07081403"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.4.1189"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP274792"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402604200"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04321.2002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/9165"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.85.5.2213"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00248-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76576"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2013.06.002"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0689-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4946-06.2007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90392-s"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/348725a0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/346177a0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.09.015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.5.1076"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2020-0018"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep05635"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0535-1"},{"key":"e_1_2_10_30_1","volume-title":"The rat brain in stereotaxic coordinates: Hard cover edition","author":"Paxinos G.","year":"2006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3710"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2617-09.2009"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-011-0706-x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07093.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01271.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90210-j"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00143.2007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0281-0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03640.1995"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2019.108526"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T05:16:01Z","timestamp":1702962961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ejn.16179"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16179","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16179\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16179\/v3\/response1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}