{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:27:16Z","timestamp":1785756436066,"version":"3.56.0"},"reference-count":84,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K22286"],"award-info":[{"award-number":["20K22286"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K13753"],"award-info":[{"award-number":["21K13753"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K07604"],"award-info":[{"award-number":["18K07604"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03579"],"award-info":[{"award-number":["19H03579"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H00630"],"award-info":[{"award-number":["19H00630"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20KK0193"],"award-info":[{"award-number":["20KK0193"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02851"],"award-info":[{"award-number":["21H02851"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19dm0107124h0004"],"award-info":[{"award-number":["JP19dm0107124h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The unconscious integration of vocal and facial cues during speech perception facilitates face\u2010to\u2010face communication. Recent studies have provided substantial behavioural evidence concerning impairments in audiovisual (AV) speech perception in schizophrenia. However, the specific neurophysiological mechanism underlying these deficits remains unknown. Here, we investigated activities and connectivities centered on the auditory cortex during AV speech perception in schizophrenia. Using magnetoencephalography, we recorded and analysed event\u2010related fields in response to auditory (A: voice), visual (V: face) and AV (voice\u2013face) stimuli in 23 schizophrenia patients (13 males) and 22 healthy controls (13 males). The functional connectivity associated with the subadditive response to AV stimulus (i.e., [AV]\u2009&lt;\u2009[A]\u2009+\u2009[V]) was also compared between the two groups. Within the healthy control group, [AV] activity was smaller than the sum of [A] and [V] at latencies of approximately 100\u2009ms in the posterior ramus of the lateral sulcus in only the left hemisphere, demonstrating a subadditive N1m effect. Conversely, the schizophrenia group did not show such a subadditive response. Furthermore, weaker functional connectivity from the posterior ramus of the lateral sulcus of the left hemisphere to the fusiform gyrus of the right hemisphere was observed in schizophrenia. Notably, this weakened connectivity was associated with the severity of negative symptoms. These results demonstrate abnormalities in connectivity between speech\u2010 and face\u2010related cortical areas in schizophrenia. This aberrant subadditive response and connectivity deficits for integrating speech and facial information may be the neural basis of social communication dysfunctions in schizophrenia.<\/jats:p>","DOI":"10.1111\/ejn.16183","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:56:09Z","timestamp":1700765769000},"page":"1918-1932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Abnormal connectivity and activation during audiovisual speech perception in schizophrenia"],"prefix":"10.1111","volume":"59","author":[{"given":"Yoji","family":"Hirano","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine University of Miyazaki  Miyazaki Japan"},{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Institute of Industrial Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itta","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine University of Miyazaki  Miyazaki Japan"},{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721417706392"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2012.05.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.12.035"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407794-2.00042-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03670.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2091-11.2011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.03.035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.08.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81138-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.11.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10919-019-00311-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509179102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00344-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scog.2021.100219"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00428-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02512476"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.05.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw103"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2003.10.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2113"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5031-07.2008"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.09.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2642"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059420914201"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059419886686"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13300"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12275"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.10.001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102022"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1934"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.156"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(91)90085-Q"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2003.09.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12098"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.08.010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq152"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.9.775"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0386"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.01.039"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.05.016"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.03.024"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00129"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.640502"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.01.009"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.03.027"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000377680"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.04.029"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.100.234101"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.554844"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13342"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13311"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.455"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.4.349"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13472"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2008.06.004"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.03.006"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/07-0276"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01784-5"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119598"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.08.008"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102909"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.06.021"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.11.037"},{"key":"e_1_2_9_68_1","first-page":"217","article-title":"Left with the voices or hearing right? Lateralization of auditory verbal hallucinations in schizophrenia","volume":"28","author":"Sommer I. E.","year":"2003","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-85"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.04.038"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.12.1964"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.07.017"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000359955"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(00)00081-0"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.03.003"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.08.041"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.04.023"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/7\/008"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.04.019"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.10.043"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.07.009"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408949102"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00565"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00107"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2013.866892"}],"updated-by":[{"DOI":"10.1111\/ejn.16432","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000}}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:44:03Z","timestamp":1717980243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":84,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/ejn.16183"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16183","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16183\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16183\/v3\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"2023-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}