{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:54:08Z","timestamp":1783727648556,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["GR 508\/20"],"award-info":[{"award-number":["GR 508\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 857\/29\u20101"],"award-info":[{"award-number":["GR 857\/29\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Harmful alcohol consumption is a major socioeconomic burden to the health system, as it can be the cause of mortality of heavy alcohol drinkers. The dopaminergic (DAergic) system is thought to play an important role in the pathogenesis of alcohol drinking behaviour; however, its exact role remains elusive. Fibroblast growth factor 2 (FGF\u20102), a neurotrophic factor, associated with both the DAergic system and alcohol consumption, may play an important role in DAergic neuroadaptations during alcohol abuse. Within this study, we aimed to clarify the role of endogenous FGF\u20102 on the DAergic system and whether there is a possible link to alcohol consumption. We found that lack of FGF\u20102 reduces the alcohol intake of mice. Transcriptome analysis of DAergic neurons revealed that FGF\u20102 knockout (FGF\u20102 KO) shifts the molecular fingerprint of midbrain dopaminergic (mDA) neurons to DA subtypes of the ventral tegmental area (VTA). In line with this, proteomic changes predominantly appear also in the VTA. Interestingly, these changes led to an altered regulation of the FGF\u20102 signalling cascades and DAergic pathways in a region\u2010specific manner, which was only marginally affected by voluntary alcohol consumption. Thus, lack of FGF\u20102 not only affects the gene expression but also the proteome of specific brain regions of mDA neurons. Our study provides new insights into the neuroadaptations of the DAergic system during alcohol abuse and, therefore, comprises novel targets for future pharmacological interventions.<\/jats:p>","DOI":"10.1111\/ejn.16234","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T01:00:53Z","timestamp":1704675653000},"page":"1519-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A dual\u2010omics approach on the effects of fibroblast growth factor\u20102 (FGF\u20102) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice"],"prefix":"10.1111","volume":"59","author":[{"given":"Leonie","family":"Hose","sequence":"first","affiliation":[{"name":"Hannover Medical School Institute of Neuroanatomy and Cell Biology  Hannover Germany"},{"name":"Center for Systems Neuroscience (ZSN)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Katharina","family":"Langenhagen","sequence":"additional","affiliation":[{"name":"Hannover Medical School Institute of Neuroanatomy and Cell Biology  Hannover Germany"},{"name":"Department of Veterinary Pathology Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterini","family":"Kefalakes","sequence":"additional","affiliation":[{"name":"Hannover Medical School Institute of Neuroanatomy and Cell Biology  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Institute of Toxicology  Hannover Germany"},{"name":"Core Facility Proteomics Institute of Toxicology  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Kubinski","sequence":"additional","affiliation":[{"name":"Hannover Medical School Institute of Neuroanatomy and Cell Biology  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segev","family":"Barak","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Pich","sequence":"additional","affiliation":[{"name":"Institute of Toxicology  Hannover Germany"},{"name":"Core Facility Proteomics Institute of Toxicology  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Grothe","sequence":"additional","affiliation":[{"name":"Hannover Medical School Institute of Neuroanatomy and Cell Biology  Hannover Germany"},{"name":"Center for Systems Neuroscience (ZSN)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02213.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.10.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20228"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00532-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021535"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12152"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23138"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811507106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00443"},{"key":"e_1_2_10_15_1","first-page":"1","article-title":"Cellular localization of brain monoamines","volume":"56","author":"Carlsson A.","year":"1962","journal-title":"Acta Physiologica Scandinavica. Supplementum"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711755105"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2014.01.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_2_10_19_1","first-page":"231","article-title":"Evidence for the existence of monoamine\u2010containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons","volume":"232","author":"Dahlstroem A.","year":"1964","journal-title":"Acta Physiologica Scandinavica. Supplementum"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.15.4213"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.01.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0805-19.2019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13115"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0890-17.2017"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2001.03477.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00669-3"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-03-02021.1995"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2006.12.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201700016"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01061-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0152-18.2018"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.027"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.022"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a039271"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677213516312"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14160"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1549"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0203-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.01.004"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.008"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07768.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0906"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-003-0756-7"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.03.003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.85"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108094"},{"key":"e_1_2_10_47_1","article-title":"Acamprosate for alcohol dependence","volume":"9","author":"R\u00f6sner S.","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.11.057"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907143106"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.028"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab446"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08453-1"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4493-06.2007"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.02.003"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-06006.1999"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.04.010"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:37:32Z","timestamp":1739205452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,7]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/ejn.16234"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16234","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16234\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16234\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16234\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16234\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16234\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16234\/v1\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,7]]},"assertion":[{"value":"2023-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}