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Post\u2010stroke cognitive and motor impairments diminish quality of life and functional independence. There is an increased risk of having a second stroke and developing secondary conditions with long\u2010term social and economic impacts. With increasing number of stroke incidents, shortage of medical professionals and limited budgets, health services are struggling to provide a care that can break the vicious cycle of stroke. Effective post\u2010stroke recovery hinges on holistic, integrative and personalized care starting from improved diagnosis and treatment in clinics to continuous rehabilitation and support in the community. To improve stroke care pathways, there have been growing efforts in discovering biomarkers that can provide valuable insights into the neural, physiological and biomechanical consequences of stroke and how patients respond to new interventions. In this review paper, we aim to summarize recent biomarker discovery research focusing on three modalities (brain imaging, blood sampling and gait assessments), look at some established and forthcoming biomarkers, and discuss their usefulness and complementarity within the context of comprehensive stroke care. We also emphasize the importance of biomarker guided personalized interventions to enhance stroke treatment and post\u2010stroke recovery.<\/jats:p>","DOI":"10.1111\/ejn.16245","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T01:25:10Z","timestamp":1705281910000},"page":"1789-1818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biochemical, biomechanical and imaging biomarkers of ischemic stroke: Time for integrative thinking"],"prefix":"10.1111","volume":"59","author":[{"given":"Meryem \u015eahin","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra S\u00fcmer","family":"Arpak","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemre Su Kaya","family":"Keles","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University  Istanbul Turkey"},{"name":"Institute of Structural Mechanics and Dynamics in Aerospace Engineering University of Stuttgart  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Villagra","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Aberystwyth University  Aberystwyth Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin \u00d6zt\u00fcrk","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazire","family":"Af\u015far","sequence":"additional","affiliation":[{"name":"Neurology Ac\u0131badem Mehmet Ali Ayd\u0131nlar University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can A.","family":"Yucesoy","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Bo\u011fazi\u00e7i University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A. 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