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One key feature of the DNLL is the generation of a strong, prolonged, ionotropic, GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor\u2010mediated inhibition. Possible GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor\u2010mediated signalling is unexplored in the DNLL. Here, we used Mongolian gerbils of either sex to describe GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor\u2010mediated modulation of postsynaptic potassium currents and synaptic inputs in postnatal (P) animals of days 10\/11 and 23\u201328. Throughout development, we observed the presence of a Baclofen\u2010activated GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor\u2010enhanced potassium outward conductance that is capable of suppressing action potential generation. In P10\/11, old gerbils GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor activation enhances glutamatergic and suppresses ionotropic GABAergic synaptic transmission. During development, this differential modulation becomes less distinct, because in P22\u201328, old animals Baclofen\u2010activated GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptors rather enhance ionotropic GABAergic synaptic transmission, whereas glutamatergic transmission is both enhanced and suppressed. Blocking GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptors causes an increase in ionotropic GABAergic transmission in P10\/11 old gerbils that was independent on stimulation frequency but depended on the type of short\u2010term plasticity. Together with the lack of Baclofen\u2010induced changes in the synaptic paired\u2010pulse ratio of either input type, we suggest that GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor\u2010mediated modulation is predominantly postsynaptic and activates different signalling cascades. Thus, we argue that in DNLL neurons, the GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor is a post\u2010synaptically located signalling hub that alters signalling cascades during development for distinct targets.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16246","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T06:50:49Z","timestamp":1704437449000},"page":"966-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GABA\n                    <sub>B<\/sub>\n                    receptor\u2010mediated modulation in the developing dorsal nucleus of the lateral lemniscus"],"prefix":"10.1111","volume":"59","author":[{"given":"Amina","family":"Javadova","sequence":"first","affiliation":[{"name":"Institute for Zoology University of Veterinary Medicine Foundation, Hannover  Hannover Germany"},{"name":"Infection Medicine and Veterinary Sciences (HGNI) 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