{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:32:56Z","timestamp":1776871976998,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971237"],"award-info":[{"award-number":["81971237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The brain's dynamic spontaneous neural activity is significant in supporting cognition; however, how brain dynamics go awry in subjective cognitive decline (SCD) and mild cognitive impairment (MCI) remains unclear. Thus, the current study aimed to investigate the dynamic amplitude of low\u2010frequency fluctuation (dALFF) alterations in patients at high risk for Alzheimer's disease and to explore its correlation with clinical cognitive assessment scales, to identify an early imaging sign for these special populations. A total of 152 participants, including 72 SCD patients, 44 MCI patients and 36 healthy controls (HCs), underwent a resting\u2010state functional magnetic resonance imaging and were assessed with various neuropsychological tests. The dALFF was measured using sliding\u2010window analysis. We employed canonical correlation analysis (CCA) to examine the bi\u2010multivariate correlations between neuropsychological scales and altered dALFF among multiple regions in SCD and MCI patients. Compared to those in the HC group, both the MCI and SCD groups showed higher dALFF values in the right opercular inferior frontal gyrus (voxel\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001, cluster\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05, correction). Moreover, the CCA models revealed that behavioural tests relevant to inattention correlated with the dALFF of the right middle frontal gyrus and right opercular inferior frontal gyrus, which are involved in frontoparietal networks (R\u2009=\u2009.43,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.024). In conclusion, the brain dynamics of neural activity in frontal areas provide insights into the shared neural basis underlying SCD and MCI.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16267","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:21:31Z","timestamp":1707268891000},"page":"2391-2402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered dynamic amplitude of low\u2010frequency fluctuation in individuals at high risk for Alzheimer's disease"],"prefix":"10.1111","volume":"59","author":[{"given":"Qin\u2010qin","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010yuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Rehabilitation Center The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medical imaging Jingjiang People's Hospital  Jingjiang 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