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Based on in vitro studies, dopamine D1\u2010type receptors in the anterior cingulate cortex and the hippocampus have been proposed to participate in this peculiar co\u2010morbidity in mouse models of amyloidosis. Here, we tested the implication of dopaminergic transmission in vivo in the Tg2576 mouse model of Alzheimer's disease by monitoring epileptic activities via intracranial EEG before and after treatment with dopamine antagonists. Our results show that neither the D1\u2010like dopamine receptor antagonist SCH23390 nor the D2\u2010like dopamine receptor antagonist haloperidol reduces the frequency of epileptic activities. While requiring further investigation, our results indicate that on a systemic level, dopamine receptors are not significantly contributing to epilepsy observed in vivo in this mouse model of Alzheimer's disease.<\/jats:p>","DOI":"10.1111\/ejn.16268","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T04:34:10Z","timestamp":1706934850000},"page":"1558-1566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["No major effect of dopamine receptor 1\/5 antagonist SCH\u201023390 on epileptic activity in the Tg2576 mouse model of amyloidosis"],"prefix":"10.1111","volume":"59","author":[{"given":"Anna","family":"B. 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