{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:47:05Z","timestamp":1789638425039,"version":"4.0.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deficits in cost\/benefit decision making is a critical risk factor for gambling disorder. Reward\u2010paired cues may play an important role, as these stimuli can enhance risk preference in rats. Despite extensive research implicating the dorsal striatum in the compulsive aspects of addiction, the role of nigrostriatal dopaminergic activity in cue\u2010induced risk preference remains unclear, particularly in females. Accordingly, we examined the effects of manipulating the dopaminergic nigrostriatal pathway on cue\u2010induced risky choice in female rats. TH:Cre rats were trained on the cued version of the rat Gambling Task. This task was designed such that maximal reward is attained by avoiding the high\u2010risk, high\u2010reward options and instead favouring the options associated with lower per\u2010trial gains, as they feature less frequent and shorter time\u2010out penalties. Adding reward\u2010paired audiovisual cues to the task leads to greater risky choice on average. To assess the role of the nigrostriatal pathway, a viral vector carrying either Cre\u2010dependent inhibitory or excitatory DREADD was infused into the substantia nigra. Rats then received clozapine\u2010N\u2010oxide either during task acquisition or after a stable performance baseline was reached. Inhibition of this pathway accelerated the development of risk preference in early sessions and increased risky choice during performance, but long\u2010term inhibition actually improved decision making. Activation of this pathway had minimal effects. These results provide evidence for the involvement of the dopaminergic nigrostriatal pathway in cue\u2010induced risk preference in females, therefore shedding light on its role in cost\/benefit decision\u2010making deficits and expanding our knowledge of the female dopaminergic system.<\/jats:p>","DOI":"10.1111\/ejn.16287","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T03:15:56Z","timestamp":1708312556000},"page":"1621-1637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dopamine activity in the nigrostriatal pathway alters cue\u2010induced risky choice patterns in female rats"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-2199","authenticated-orcid":false,"given":"Brett A.","family":"Hathaway","sequence":"first","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah G.","family":"Brodie","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason M.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Soo","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine A.","family":"Winstanley","sequence":"additional","affiliation":[{"name":"Department of Psychology, Djavad Mowafaghian Centre for Brain Health University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0028-3908(98)00033-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140045"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2225-15.2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(94)90018-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.4\/jbecker"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00505.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120972421"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_382"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.163"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.05.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1171-18.2018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05806-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.12.1136"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1560"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12028"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.05.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.02.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-15179-9_35"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.01.017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-06-02369.2000"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0341-21.2021"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.09.040"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.05.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.029"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.08.021"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000372"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13022"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09263"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674379403900509"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.014"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00312"},{"key":"e_1_2_10_35_1","volume-title":"Handbook of biological statistics","author":"McDonald J. H.","year":"2009"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1459-22.2022"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.104"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5445-13.2014"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.325"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0191-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1593"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000135"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.033"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122063"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.036"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116674"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70287-X"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1713-16.2016"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq239"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.08.001"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03095.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2261"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04218.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2018.04.002"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4072-10.2010"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.62"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26653"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:37:17Z","timestamp":1739205437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/ejn.16287"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16287","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16287\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16287\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"2023-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}