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However, most neuroimaging studies have focused on impairments in either resting\u2010state or task\u2010related functional connectivity in patients with schizophrenia. The aims of our study were to examine (1) blood oxygen level\u2010dependent (BOLD) signals during auditory steady\u2010state response (ASSR) tasks, (2) functional connectivity during the resting\u2010state and ASSR tasks and (3) state shifts between the resting\u2010state and ASSR tasks in patients with schizophrenia. To reduce the functional consequences of scanner noise, we employed resting\u2010state and sparse sampling auditory fMRI paradigms in 25 schizophrenia patients and 25 healthy controls. Auditory stimuli were binaural click trains at frequencies of 20, 30, 40 and 80\u2009Hz. Based on the detected ASSR\u2010evoked BOLD signals, we examined the functional connectivity between the thalamus and bilateral auditory cortex during both the resting state and ASSR task state, as well as their alterations. The schizophrenia group exhibited significantly diminished BOLD signals in the bilateral auditory cortex and thalamus during the 80\u2009Hz ASSR task (corrected\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). We observed a significant inverse relationship between the resting state and ASSR task state in altered functional connectivity within the thalamo\u2010auditory network in schizophrenia patients. Specifically, our findings demonstrated stronger functional connectivity in the resting state (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.004) and reduced functional connectivity during the ASSR task (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048), which was mediated by abnormal state shifts, within the schizophrenia group. These results highlight the presence of abnormal thalamocortical connectivity associated with deficits in the shift between resting and task states in patients with schizophrenia.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16298","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T05:41:38Z","timestamp":1709617298000},"page":"1961-1976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aberrant thalamocortical connectivity and shifts between the resting state and task state in patients with schizophrenia"],"prefix":"10.1111","volume":"59","author":[{"given":"Yoshifumi","family":"Takai","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department 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