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The positron emission tomography (PET) radioligand sensitive to tau neurofibrillary tangles (\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010AV1451) also binds with iron. This off\u2010target binding effect may be enhanced in older adults on the AD spectrum, particularly those with amyloid\u2010positive biomarkers. Here, we examined group differences in\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010AV1451 PET after controlling for iron\u2010sensitive measures from magnetic resonance imaging (MRI) and its relationships to tissue microstructure and cognition in 40 amyloid beta positive (A\u03b2+) individuals, 20 amyloid beta negative (A\u03b2\u2010) with MCI and 31 A\u03b2\u2010 control participants. After controlling for iron, increased\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010AV1451 PET uptake was found in the temporal lobe and hippocampus of A\u03b2+\u2009participants compared to A\u03b2\u2010 MCI and control participants. Within the A\u03b2+\u2009group, significant correlations were seen between\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010AV1451 PET uptake and tissue microstructure and these correlations remained significant after controlling for iron. These findings indicate that off\u2010target binding of iron to the\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010AV1451 ligand may not affect its sensitivity to A\u03b2 status or cognition in early\u2010stage AD.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16362","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:59:00Z","timestamp":1715245140000},"page":"3614-3628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Examining iron\u2010related off\u2010target binding effects of\n                    <sup>18<\/sup>\n                    F\u2010AV1451 PET in the cortex of A\u03b2+ individuals"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-1265","authenticated-orcid":false,"given":"Jason","family":"Langley","sequence":"first","affiliation":[{"name":"Center for Advanced Neuroimaging University of California 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