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Epithelial stem cells give rise to new neurons that can adequately replace dying olfactory receptor neurons (ORNs) during developmental and adult phases and after lesions. To relay olfactory information from the environment to the brain, the axons of the renewed ORNs must reconnect with the olfactory bulb (OB). In\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Xenopus laevis<\/jats:italic>\n                    <\/jats:styled-content>\n                    larvae, we have previously shown that this process occurs between 3 and 7\u2009weeks after olfactory nerve (ON) transection. In the present study, we show that after 7\u2009weeks of recovery from ON transection, two functionally and spatially distinct glomerular clusters are reformed in the OB, akin to those found in non\u2010transected larvae. We also show that the same odourant response tuning profiles observed in the OB of non\u2010transected larvae are again present after 7\u2009weeks of recovery. Next, we show that characteristic odour\u2010guided behaviour disappears after ON transection but recovers after 7\u20139\u2009weeks of recovery. Together, our findings demonstrate that the olfactory system of larval\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>X. laevis<\/jats:italic>\n                    <\/jats:styled-content>\n                    regenerates with high accuracy after ON transection, leading to the recovery of odour\u2010guided behaviour.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16375","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:57:25Z","timestamp":1715950645000},"page":"3719-3741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The olfactory network of larval\n                    <scp>\n                      <i>Xenopus laevis<\/i>\n                    <\/scp>\n                    regenerates accurately after olfactory nerve 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