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Individual and disease\u2010related variability in intrinsic connectivity networks may influence our interpretation of R\u2010fMRI data. We used a personalized approach designed to account for individual variation in the spatial location of correlation maxima to evaluate R\u2010fMRI differences between Parkinson's disease (PD) patients who showed cognitive decline, those who remained cognitively stable and cognitively stable controls. We compared fMRI data from these participant groups, studied at baseline and 18\u2009months later, using both network\u2010based statistics (NBS) and calculations of mean inter\u2010 and intra\u2010network connectivity within pre\u2010defined functional networks. The NBS analysis showed that PD participants who remained cognitively stable showed exclusively (at baseline) or predominantly (at follow\u2010up) increased intra\u2010network connectivity, whereas decliners showed exclusively reduced intra\u2010network and inter\u2010 (ventral attention and default mode) connectivity, in comparison with the control group. Evaluation of mean connectivity between all regions of interest (ROIs) within a priori networks showed that decliners had consistently reduced inter\u2010network connectivity for ventral attention, somatomotor, visual and striatal networks and reduced intra\u2010network connectivity for ventral attention network to striatum and cerebellum. These findings suggest that specific functional connectivity covariance patterns differentiate PD cognitive subtypes and may predict cognitive decline. Further, increased intra and inter\u2010network synchrony may support cognitive function in the face of PD\u2010related network disruptions.<\/jats:p>","DOI":"10.1111\/ejn.16380","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T05:45:51Z","timestamp":1715838351000},"page":"3795-3811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A longitudinal evaluation of personalized intrinsic network topography and cognitive decline in Parkinson's disease"],"prefix":"10.1111","volume":"60","author":[{"given":"Renxi","family":"Li","sequence":"first","affiliation":[{"name":"William S. Middleton V.A. 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