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Understanding age\u2010related changes in the circadian system at a systemic level can contribute to the development of strategies to promote healthy ageing. The goal of this study was to investigate the impact of ageing on 24\u2010h rhythms in amine metabolites across four tissues in young (2\u00a0months of age) and old (22\u201325\u2009months of age) mice using a targeted metabolomics approach. Liver, plasma, the suprachiasmatic nucleus (SCN; the location of the central circadian clock in the hypothalamus) and the paraventricular nucleus (PVN; a downstream target of the SCN) were collected from young and old mice every 4\u00a0h during a 24\u2010h period (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20096\u20137 mice per group). Differential rhythmicity analysis revealed that ageing impacts 24\u2010h rhythms in the amine metabolome in a tissue\u2010specific manner. Most profound changes were observed in the liver, in which rhythmicity was lost in 60% of the metabolites in aged mice. Furthermore, we found strong correlations in metabolite levels between the liver and plasma and between the SCN and the PVN in young mice. These correlations were almost completely abolished in old mice. These results indicate that ageing is accompanied by a severe loss of the circadian coordination between tissues and by disturbed rhythmicity of metabolic processes. The tissue\u2010specific impact of ageing may help to differentiate mechanisms of ageing\u2010related disorders in the brain versus peripheral tissues and thereby contribute to the development of potential therapies for these disorders.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16428","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T19:39:07Z","timestamp":1716838747000},"page":"3843-3857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Loss of temporal coherence in the circadian metabolome across multiple tissues during ageing in mice"],"prefix":"10.1111","volume":"60","author":[{"given":"M. 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