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We assessed the receptor function in hiPSC\u2010derived cortical and SCG neurons with Fura\u20102 calcium imaging and three different \u03b17\u2010specific ligands: PNU282987, choline, and 4BP\u2010TQS. Given the short\u2010lived open state of \u03b17 receptors, we combined the two orthosteric agonists PNU282987 and choline with the type\u20102 positive allosteric modulator (PAM II) PNU120596. In line with different cellular models used previously, we demonstrate that\n                    <jats:italic>CHRFAM7A<\/jats:italic>\n                    has a major impact on nicotinic \u03b17 nAChRs by reducing calcium transients in response to all three agonists.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16474","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T02:20:29Z","timestamp":1722219629000},"page":"4893-4906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The human\u2010specific nicotinic receptor subunit CHRFAM7A reduces \u03b17 receptor function in human induced pluripotent stem cells\u2010derived and transgenic mouse neurons"],"prefix":"10.1111","volume":"60","author":[{"given":"Ilayda","family":"G\u00f6rg\u00fcl\u00fc","sequence":"first","affiliation":[{"name":"Center for Brain Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-8181","authenticated-orcid":false,"given":"Vinita","family":"Jagannath","sequence":"additional","affiliation":[{"name":"Institut du Fer \u00e0 Moulin Sorbonne University, UMR\u2010S 1270  Paris France"},{"name":"MSD R&amp;D Innovation Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Pons","sequence":"additional","affiliation":[{"name":"Integrative Neurobiology of Cholinergic Systems, Institut Pasteur Universit\u00e9 Paris Cit\u00e9, UMR 3571  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Koniuszewski","sequence":"additional","affiliation":[{"name":"Center for Brain Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Groszer","sequence":"additional","affiliation":[{"name":"Institut du Fer \u00e0 Moulin Sorbonne University, UMR\u2010S 1270  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Maskos","sequence":"additional","affiliation":[{"name":"Integrative Neurobiology of Cholinergic Systems, Institut Pasteur Universit\u00e9 Paris Cit\u00e9, UMR 3571  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigismund","family":"Huck","sequence":"additional","affiliation":[{"name":"Center for Brain Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-6034","authenticated-orcid":false,"given":"Petra","family":"Scholze","sequence":"additional","affiliation":[{"name":"Center for Brain Research Medical University of Vienna  Vienna 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