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We aimed to investigate the feasibility of expert\u2010placed, high\u2010resolution T1\u2010weighted ROI\u2010data transfer onto lower spatial resolution diffusion\u2010weighted images.<\/jats:p>\n                  <jats:p>Slab volumes from 20 volunteers were acquired and preprocessed including distortion bias correction and artifact reduction. Constrained spherical deconvolution was used to generate a directional diffusion information grid (fibre orientation distribution\u2010model [FOD]). Three neuroradiologists marked landmarks on both diffusion imaging variants and structural datasets. Structural ROI information (volumetric interpolated breath\u2010hold sequence [VIBE]) was respectively registered (linear with 6\/12 degrees of freedom [DOF]) onto single\u2010shot EPI (ss\u2010EPI) and readout\u2010segmented EPI (rs\u2010EPI) volumes, respectively. All eight ROI\/FOD\u2010combinations were compared in a targeted tractography task of the optic nerve pathway.<\/jats:p>\n                  <jats:p>Inter\u2010rater reliability for placed ROIs among experts was highest in VIBE images (lower confidence interval 0.84 to 0.97, mean 0.91) and lower in both ss\u2010EPI (0.61 to 0.95, mean 0.79) and rs\u2010EPI (0.59 to 0.86, mean 0.70).<\/jats:p>\n                  <jats:p>Tractography success rate based on streamline selection performance was highest in VIBE\u2010drawn ROIs registered (6\u2010DOF) onto rs\u2010EPI FOD (70.0% over 5%\u2010threshold, capped to failed ratio 39\/16) followed by both 12\u2010DOF\u2010registered (67.5%; 41\/16) and nonregistered VIBE (67.5%; 40\/23). On ss\u2010EPI FOD, VIBE\u2010ROI\u2010datasets obtained fewer streamlines overall with each at 55.0% above 5%\u2010threshold and with lower capped to failed ratio (6\u2010DOF: 35\/36; 12\u2010DOF: 34\/34, nonregistered 33\/36).<\/jats:p>\n                  <jats:p>The combination of VIBE\u2010placed ROIs (highest inter\u2010rater reliability) with 6\u2010DOF registration onto rs\u2010EPI targets (best streamline selection performance) is most suitable for white matter template generation required in group studies.<\/jats:p>","DOI":"10.1111\/ejn.16490","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T23:50:11Z","timestamp":1722469811000},"page":"4987-4999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of T1\u2010weighted landmark placement and ROI transfer onto diffusion\u2010weighted EPI sequences for targeted tractography tasks in the optic nerve"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-0518","authenticated-orcid":false,"given":"Markus","family":"Janko","sequence":"first","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha D.","family":"Santaniello","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Brockmann","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils F.","family":"Grauhan","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa I.","family":"Sch\u00f6ffling","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Dimova","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Ponto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kleinekofort","sequence":"additional","affiliation":[{"name":"Applied Physics &amp; 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