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Here, I argue that philosophy of science can improve the chance of constructive debate by giving researchers technical language to describe and assess scientific progress. To do so, I interpret the amyloid hypothesis using a modified version of the research programme concept from philosopher of science Imre Lakatos. I first outline the amyloid\u2010\u03b2 hypothesis and study critiques of its central place in Alzheimer's research. Then, I draw on the complexity of amyloid\u2010\u03b2 and Alzheimer's research to discuss the limits of using concepts from popular philosophers of science Karl Popper or Thomas Kuhn, before finally arguing that an adaptation of the research programme concept can foster constructive debates about the science of Alzheimer's and within it. I will argue that the amyloid\u2010\u03b2 hypothesis has contributed to significant progress in the Alzheimer's field based on what Lakatos called the \u201cpositive heuristic\u201d (motivating the programme to test its predictions) and the \u201cnegative heuristic\u201d (protecting the programme from refutation). I consider the amyloid research agenda to be progressive despite the fact that its claims about disease aetiology could be wrong.<\/jats:p>","DOI":"10.1111\/ejn.16500","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T07:23:47Z","timestamp":1723188227000},"page":"4707-4722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A philosophy of science approach to the amyloid hypothesis of Alzheimer's disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-242X","authenticated-orcid":false,"given":"Timothy","family":"Daly","sequence":"first","affiliation":[{"name":"Bioethics Program, FLACSO Argentina  Buenos Aires Argentina"},{"name":"Science Norms Democracy UMR 8011 Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature.2016.21045"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12192"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S302"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1353\/book.3237"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.08.014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/016224399401900106"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00019-9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.1531"},{"key":"e_1_2_13_11_1","volume-title":"The Stanford encyclopedia of philosophy (fall 2023). 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