{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:43:48Z","timestamp":1777085028647,"version":"3.51.4"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004801","name":"Shota Rustaveli National Science Foundation","doi-asserted-by":"publisher","award":["FR\u201021\u20101501"],"award-info":[{"award-number":["FR\u201021\u20101501"]}],"id":[{"id":"10.13039\/501100004801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The detrimental effects of high\u2010intensity noise on the auditory system and emotional status, including the induction of anxiety, are well documented. Preclinical as well as epidemiological and clinical studies have solidly established differential responses between males and females to various stressful stimuli, including high\u2010intensity white noise (HIWN). However, whether chronic exposure to noise affects cognitive functions and whether this effect is sex dependent has not been adequately addressed. In this study, we used two cognitive test paradigms, such as the Morris water maze (MWM) and the multi\u2010branch maze (MBM), to test the effect of chronic HIWN on indices of spatial learning and memory in both male and female Wistar rats. Our findings indicate that daily (1\u2009h) exposure to 100\u2009dB of noise for 30 consecutive days induces different task\u2010dependent responses in male versus female rats. For example, in the acquisition phase of MWM, female rats exposed to noise outperformed their male counterparts at twice the speed. Similarly, in the MBM test, noise\u2010exposed female rats outperformed the male rats in reaching the nest box. It is clear from these studies that noise impairs cognitive functions twice as negatively in male rats as in female rats. Thus, sex\u2010related differences in spatial learning and memory in response to HIWN must be taken into consideration when investigating the neurobiological components and\/or treatment modalities.<\/jats:p>","DOI":"10.1111\/ejn.16514","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T02:43:47Z","timestamp":1724467427000},"page":"5581-5590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of high\u2010intensity chronic noise on spatial memory in male versus female rats"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-8428","authenticated-orcid":false,"given":"Mzia G.","family":"Zhvania","sequence":"first","affiliation":[{"name":"School of Natural Sciences and Medicine Ilia State University  Tbilisi Georgia"},{"name":"Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadezhda","family":"Japaridze","sequence":"additional","affiliation":[{"name":"Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine  Tbilisi Georgia"},{"name":"Carl Zeiss Scientific and Education Center New Vision University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Tizabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Howard University College of Medicine  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nino","family":"Pochkhidze","sequence":"additional","affiliation":[{"name":"Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgi","family":"Lobzhanidze","sequence":"additional","affiliation":[{"name":"Department of Brain Ultrastructure and Nanoarchitecture I. Beritashvili Center of Experimental Biomedicine  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141215898"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-020-00074-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1077409"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000001322"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010591"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP10959"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000690"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/29542"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010288"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/nah.NAH_23_19"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2019.100818"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2008-15406"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01132-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1143024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008200107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135543"},{"key":"e_1_2_10_18_1","first-page":"178","article-title":"The effect of high intensity white noise on the ultrastructure of axo\u2010dendritic synapses in colliculus inferior of adult male cats. Quantitative electron microscopic study","volume":"320","author":"Gogokhia N.","year":"2021","journal-title":"Georgian Medical News"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137571"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107306"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/17588928.2020.1853087"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12574"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2019.742"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13917.1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-17618-z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29100-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173168"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.08.021"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1138118"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10011"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22839"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2023.1100505"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2010.07.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12040632"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0171-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/23312165221076940"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1044\/2021_JSLHR-20-00153"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5859"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.21-0120"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13020185"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/nah.NAH_26_20"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2022.2086706"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00466-8"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13216"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18189856"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0442-7"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212208"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.5111870"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2022.105112"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106905"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.160234"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006396.pub4"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106384"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/nah.nah_3_22"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40660-1"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-022-00771-0"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.116"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.065"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050934"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1998.1466"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0292321"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-22351-y"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017841117"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134898"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136390"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T02:36:58Z","timestamp":1727923018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/ejn.16514"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16514","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16514\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16514\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16514\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16514\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16514\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16514\/v2\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}