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The soluble guanylate cyclase (sGC) within the PVN is implicated in autonomic and cardiovascular control in rodents under resting conditions. However, the involvement of PVN sGC\u2010mediated signalling in stress responses is unknown. Therefore, we investigated the role of sGC within the PVN in cardiovascular, autonomic, neuroendocrine, and local neuronal responses to acute restraint stress in rats. Bilateral microinjection of the selective sGC inhibitor ODQ (1\u00a0nmol\/100\u2009nl) into the PVN reduced both the increased arterial pressure and the drop in cutaneous tail temperature evoked by restraint stress, while the tachycardia was enhanced. Intra\u2010PVN injection of ODQ did not alter the number of Fos\u2010immunoreactive neurons in either the dorsal cap parvocellular (PaDC), ventromedial (PaV), medial parvocellular (PaMP), or lateral magnocelllular (PaLM) portions of the PVN following acute restraint stress. Local microinjection of ODQ into the PVN did not affect the restraint\u2010induced increases in plasma corticosterone concentration. Taken together, these findings suggest that sGC\u2010mediated signalling in the PVN plays a key role in acute stress\u2010induced pressor responses and sympathetically mediated cutaneous vasoconstriction, whereas the tachycardiac response is inhibited. Absence of an effect of ODQ on corticosterone and PVN neuronal activation in and the PaV and PaMP suggests that PVN sGC is not involved in restraint\u2010evoked hypothalamus\u2010pituitary\u2010adrenal (HPA) axis activation and further indicates that autonomic and neuroendocrine responses are dissociable at the level of the PVN.<\/jats:p>","DOI":"10.1111\/ejn.16527","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T09:39:39Z","timestamp":1725529179000},"page":"5849-5860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-9579","authenticated-orcid":false,"given":"Cristiane","family":"Busnardo","sequence":"first","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-858X","authenticated-orcid":false,"given":"Carlos C.","family":"Crestani","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"},{"name":"Department of Pharmacology and Systems Physiology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Fassini","sequence":"additional","affiliation":[{"name":"Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases Massachusetts General Hospital and Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca M.","family":"Scarambone","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Packard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Physiology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo B. 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