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Age\u2010related deterioration in gap detection ability, resulting in poor temporal auditory processing, is often attributed to pathophysiological changes in both the peripheral and central auditory systems. This study aimed to investigate whether the gap detection ability declines in the early stages of ageing and to determine its usefulness in detecting peripheral and central auditory degeneration. The study used 1\u2010month\u2010old (1\u00a0M), 6\u2010month\u2010old (6\u00a0M) and 12\u2010month\u2010old (12\u2009M) mice to examine changes in gap detection ability and associated auditory pathophysiology. Although hearing thresholds did not significantly differ between the groups, the amplitude of auditory brainstem response (ABR) wave I decreased significantly in an age\u2010dependent manner, consistent with age\u2010related cochlear synaptopathy. The relative ABR amplitude ratio of waves 2 and 5 to wave 1 was significantly increased in 12\u2009M mice, indicating that the central auditory system had increased in relative neuroactivity. A significant increase in gap detection thresholds was observed in 12\u2009M mice compared to 1\u00a0M mice. Although cochlear synaptopathy and central hyperactivity were positively correlated with gap detection thresholds, central hyperactivity strongly influenced gap detection ability. In the cochlear nucleus and auditory cortex, the inhibitory synaptic expression of GAD65 and the expression of parvalbumin were significantly decreased in 12\u2009M mice, consistent with central hyperactivity. Evaluating gap detection performance may allow the identification of decreased auditory temporal resolution in the early stages of ARHI, which is strongly associated with auditory neurodegeneration.<\/jats:p>","DOI":"10.1111\/ejn.16534","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T22:29:02Z","timestamp":1725575342000},"page":"5861-5875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gap detection ability declines with central auditory neurodegeneration following age\u2010related cochlear synaptopathy"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-8527","authenticated-orcid":false,"given":"Takaomi","family":"Kurioka","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery National Defense Medical College  Saitama 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