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Brain slices were prepared from mice knocked in two types of ARX, P355L (PL) and 333ins (GCG)7 (GCG). The input resistance of cholinergic interneurons in PL or GCG mice was significantly smaller than that in wild type (WT), whereas resting membrane potential, threshold of action potentials, spontaneous firing rate, sag ratio or afterhyperpolarization of the mutant mice were not significantly different from those of WT mice. In GCG mice, NMDA\/AMPA ratio of excitatory postsynaptic currents (EPSCs) evoked in cholinergic interneurons was significantly smaller than that in WT and PL mice, whereas the ratio between PL and WT mice was not significantly different. Although inhibitory effects induced by dopamine D2\u2010like receptor activation on the inhibitory postsynaptic currents (IPSCs) were not significantly different between WT and PL or GCG mice, increase in the paired pulse ratio of IPSCs by dopamine D2\u2010like receptor activation was abolished in PL and GCG mice. The present results have found abnormalities of neuronal activities as well as its modulation in the basal ganglia in ARX mutant mice, clarifying basic mechanisms underlying related disorders.<\/jats:p>","DOI":"10.1111\/ejn.16542","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T14:58:25Z","timestamp":1726585105000},"page":"6015-6029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synaptic and membrane properties of cholinergic interneurons in the striatum of aristaless\u2010related homeobox gene mutant mice"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-9167","authenticated-orcid":false,"given":"Toshihiko","family":"Momiyama","sequence":"first","affiliation":[{"name":"Department of Pharmacology Jikei University School of Medicine  Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-0132","authenticated-orcid":false,"given":"Takuma","family":"Nishijo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jikei University School of Medicine  Minato\u2010ku Tokyo Japan"},{"name":"Department of Molecular Neurobiology Institute for Developmental Research, Aichi Developmental Disability Center  Kasugai Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-1162","authenticated-orcid":false,"given":"Etsuko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Jikei University School of Medicine  Minato\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Mental Retardation and Birth Defect Research National Institute of Neuroscience, National Centre of Neurology and Psychiatry  Kodaira Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.1.326"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05180.1998"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs138"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.981"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105697"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0417-07.2007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.04.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy122"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1067-08.2008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn271"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018850"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101999"},{"issue":"24","key":"e_1_2_10_14_1","first-page":"00214","article-title":"Loss of postnatal Arx transcriptional activity in parvalbumin interneurons reveals non\u2010cell autonomous disturbance in CA1 pyramidal cells","volume":"0306","author":"Joseph D. 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