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This study aimed to investigate whole\u2010brain functional connectivity (FC) pattern alterations in PD patients with FOG. A total of 18 PD patients, 10 with FOG (PD\u2010FOG) and 8 without FOG (PD\u2010nFOG), and 10 healthy controls were enrolled. High\u2010resolution 3D T1\u2010weighted and resting\u2010state functional MRI (rs\u2010fMRI) data were obtained from all participants. The groups' internetwork connectivity differences were explored with rs\u2010fMRI FC using seed\u2010based analysis and graph theory. Multiple linear regression analysis estimated the relationship between FC changes and clinical measurements. Rs\u2010fMRI analysis demonstrated alterations in FC in various brain regions between the three groups. Freezing of Gait Questionnaire severity was correlated with decreased brain functional connection between Vermis12 and the left temporal occipital fusiform cortex (r\u2009=\u2009\u22120.82,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Graph theory topological metrics indicated a decreased clustering coefficient in the right superior temporal gyrus in the PD\u2010nFOG group. PD\u2010FOG patients exhibited a compensatory increase in connectivity between the left inferior frontal gyrus language network and the postcentral gyrus compared to PD\u2010nFOG patients. Further, the decreased connection between Vermis 12 and the left temporal occipital fusiform cortex may serve as a potential neuroimaging biomarker for tracking PD\u2010FOG and distinguishing between PD subtypes.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16547","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:33:53Z","timestamp":1727915633000},"page":"6279-6290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional connectivity compensation in Parkinson's disease with freezing of gait"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-1215","authenticated-orcid":false,"given":"Li\u2010Chuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences 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