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In this study, we compared single\u2010neuron activity in the GPi between 18 GTS patients (with an average of 41 cells per patient) and 17 DYS patients (with an average of 54 cells per patient), all of whom underwent bilateral pallidal stimulation surgery, under general anesthesia or while awake at rest. We found no significant differences in GPi neuronal activity characteristics between patients operated on under general anesthesia versus those who were awake, irrespective of their diagnosis (GTS or DYS). We found higher firing rates, firing rate in bursts, pause duration and interspike interval coefficient of variation in GTS patients compared to DYS patients. On the opposite, we found higher number of pauses and bursts frequency in DYS patients. Lastly, we found a higher proportion of GPi oscillatory activities in DYS compared to GTS patients, with predominant activity within the low\u2010frequency band (theta\/alpha) in both patient groups. These findings underscore the complex relationship between the different neuronal discharge characteristic such as oscillatory or bursting activity within the GPi in shaping the clinical phenotypes of hyperkinetic disorders. Further research is warranted to deepen our understanding of how neuronal patterns are transmitted within deep brain structures and to develop strategies aimed at normalizing these pathological activities, by refining DBS techniques to enhance treatment efficacy and individual outcomes.<\/jats:p>","DOI":"10.1111\/ejn.16567","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T06:08:22Z","timestamp":1728713302000},"page":"6185-6194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pallidal neuronal activity in Gilles de la Tourette syndrome and dystonic patients: A comparative study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-6301","authenticated-orcid":false,"given":"Hugues","family":"Lamothe","sequence":"first","affiliation":[{"name":"Inserm 1127, Sorbonne Universit\u00e9, UPMC Univ Paris 06, UMRS 1127, CNRS, UMR 7225, Paris Brain 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