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While these impairments are typically attributed to frontostriatal dysfunction, the neural substrates of ABM impairment in HD remain unexplored. To this end, we assessed ABM in 30 participants with genetically confirmed HD (18 premanifest, 12 manifest) and 24 age\u2010matched healthy controls. Participants completed the Autobiographical Interview to assess free and probed ABM recall and underwent structural brain imaging. Whole\u2010brain voxel\u2010based morphometry (VBM) was used to explore voxel\u2010wise associations between ABM performance and grey matter intensity (False Discovery Rate corrected at\n                    <jats:italic>q<\/jats:italic>\n                    \u00a0=\u20090.05). Relative to controls, HD participants displayed significantly less detailed ABM retrieval across free and probed recall conditions, irrespective of disease stage. Recall performance did not differ significantly between manifest and premanifest HD groups. VBM analyses indicated that poorer ABM performance was associated with atrophy of a distributed cortico\u2010subcortical network. Key regions implicated irrespective of ABM condition included the bilateral occipital cortex, left precuneus, right parahippocampal gyrus and right caudate nucleus. In addition, probed ABM recall was associated with the superior and inferior frontal gyri, frontal pole, right hippocampus, nucleus accumbens, paracingulate gyrus and cerebellum. Overall, our findings indicate that ABM impairments in HD reflect the progressive degeneration of a distributed cortico\u2010subcortical brain network comprising medial temporal, frontal, striatal and posterior parietal cortices. Our findings advance our understanding of the neurocognitive profile of HD, providing an important foundation for future interventions to support memory function in this population.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16576","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T20:58:32Z","timestamp":1729198712000},"page":"6509-6524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Delineating the neural substrates of autobiographical memory impairment in Huntington's disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-6315","authenticated-orcid":false,"given":"Kristina","family":"Horne","sequence":"first","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Psychology The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Carmichael","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University  Clayton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily\u2010Clare","family":"Mercieca","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University  Clayton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifat","family":"Glikmann\u2010Johnston","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University  Clayton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Stout","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences, Turner Institute for Brain and Mental Health Monash University  Clayton Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-8169","authenticated-orcid":false,"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Psychology The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.05.018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.03.008"},{"issue":"1","key":"e_1_2_11_4_1","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease","volume":"31","author":"Alonso M.","year":"2006","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"e_1_2_11_5_1","article-title":"Non\u2010linear optimisation. 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