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This study is aimed to investigate the stress\u2010enhanced fear learning model of PTSD in females. The model mirrors PTSD symptomology in males, whereby prior stress leads to extinction resistant exaggerated contextual fear memory. As stress reactivity is highly relevant to the study and risk for PTSD, females of the stress hyper\u2010reactive Wistar Kyoto More Immobile (WMI) and its nearly isogenic control the Wistar Kyoto Less Immobile (WLI) strains were employed. Prior studies have shown WMI females presenting unchanged or enhanced fear memory in the stress\u2010enhanced fear learning paradigm compared WLIs. The present study confirmed the enhanced fear memory following contextual fear conditioning in WMIs compared to WLI females, but this increased fear memory was neither exaggerated by prior stress nor showed extinction deficit. The novel stressor of a glucose challenge test resulted in subtle strain\u2010 and prior stress\u2010induced differences in plasma glucose responses. However, fasting plasma corticosterone levels were lower, and rose slower in response to glucose challenge in WMI females, suggesting a PTSD\u2010like dysfunctional stress response. Hippocampal expressions of genes relevant to both learning and memory and the stress response were decreased in stressed WMIs compared to WLI females, further suggesting a marked dysregulation in stress\u2010related functions like in PTSD. Thus, although WMI females do not show extinction\u2010resistant enhanced fear memory, they do present other characteristics that are relevant to PTSD in women.<\/jats:p>","DOI":"10.1111\/ejn.16595","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T23:49:21Z","timestamp":1731282561000},"page":"6851-6865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Female Wistar Kyoto More Immobile rats with genetic stress hyper\u2010reactivity show enhanced contextual fear memory without deficit in extinction of fear"],"prefix":"10.1111","volume":"60","author":[{"given":"Aspen M.","family":"Harter","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine Northwestern University  Chicago Illinois 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