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Cumulative evidence suggests an intergenerational transmission of trauma to descendants. In this way, considering the child's\n                    <jats:italic>COMT<\/jats:italic>\n                    Val\n                    <jats:sup>158<\/jats:sup>\n                    Met (rs4680: G\u2009&gt;\u2009A) variant, the study aims to investigate the interactive effect of maternal childhood trauma on the emotional\/behavioural problems of their offspring in preschoolers age (4\u20135 and 11\u2009years old) from a population\u2010based dyad of pregnant adolescent women. The behaviour problems of 310 children were assessed using the Child Behaviour Checklist (CBCL) instrument, and maternal trauma was assessed with the Child Trauma Questionnaire (CTQ) between the 20 to 22\u00b0 gestational weeks. Maternal childhood trauma increases the risk for all emotional\/behavioural problems in the offspring, and no direct association between the child's Val\n                    <jats:sup>158<\/jats:sup>\n                    Met genotypes with emotional\/behavioural problems. Interestingly, in moderation analysis adjusted by sex, age and skin colour, children of mothers exposed to childhood trauma, carrying the Val\/Met genotype, are less likely to develop externalising (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.020) and total problems (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.041) when compared to homozygous (Val\/Val and Met\/Met). Thus, our findings reinforce evidence on the intergenerational impact of maternal trauma on emotional\/behavioural problems and demonstrate that this risk is influenced by the genetic background of the individual, varying according to the functional\n                    <jats:italic>COMT<\/jats:italic>\n                    genotype, which confers a protective profile for the development of externalising and total problems.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16631","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T20:09:47Z","timestamp":1733342987000},"page":"7263-7273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>COMT<\/i>\n                    Val\n                    <sup>158<\/sup>\n                    Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children"],"prefix":"10.1111","volume":"60","author":[{"given":"Jana\u00edna","family":"Xavier","sequence":"first","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa Ribeiro","family":"Bastos","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayane Moreira","family":"Marins","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00edsa","family":"Camerini","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Epidemiology Federal University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Behling De Mello","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Antunes","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"de \u00c1vila Quevedo","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Bonati","family":"de Matos","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Tavares","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-6882","authenticated-orcid":false,"given":"Gabriele","family":"Ghisleni","sequence":"additional","affiliation":[{"name":"Post\u2010Graduated Program in Health and Behavior Catholic University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.08.009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-006x.47.2.223"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.21-8-265"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1511"},{"key":"e_1_2_11_6_1","first-page":"139","volume-title":"Origins of the social mind: Evolutionary psychology and child development","author":"Belsky J.","year":"2005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017376"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(02)00541-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300542"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2021.117954"},{"key":"e_1_2_11_11_1","unstructured":"Crit\u00e9rio Brasil C. 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