{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:36:50Z","timestamp":1785487010876,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970877"],"award-info":[{"award-number":["81970877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171159"],"award-info":[{"award-number":["82171159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to investigate the topological properties of brain functional networks in patients with tinnitus of varying durations. A total of 51 tinnitus patients (divided into recent\u2010onset tinnitus (ROT) and persistent tinnitus (PT) groups) and 27 healthy controls (HC) were recruited. All participants underwent resting\u2010state functional MRI and audiological assessments. Graph theory was used to examine brain network topology.<\/jats:p>\n                  <jats:p>\n                    The results showed that the ROT group exhibited lower clustering coefficient, gamma, sigma and local efficiency compared to both the HC and PT groups (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Significant reductions in nodal clustering coefficient and local efficiency were found in the left caudate nucleus and left olfactory cortex, while increased nodal centralities were observed in the left orbital middle frontal gyrus and left postcentral gyrus in ROT patients (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore, the ROT group had decreased nodal clustering in the right lenticular putamen and reduced nodal efficiency in the left olfactory cortex compared to both PT patients and HCs (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05).\n                  <\/jats:p>\n                  <jats:p>Additionally, PT patients showed weaker functional connectivity between the subcortical and occipital lobe modules, as well as between the prefrontal and intra\u2010frontal modules, compared to ROT patients. However, intra\u2010module connectivity in the subcortical module was stronger in PT patients than in HCs.<\/jats:p>\n                  <jats:p>These findings suggest that recent\u2010onset tinnitus is associated with alterations in brain network topology, but many of these changes are restored with the persistence of tinnitus.<\/jats:p>","DOI":"10.1111\/ejn.16643","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:16:02Z","timestamp":1736756162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Topological features of brain functional networks are reorganized during chronic tinnitus: A graph\u2010theoretical study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-4232","authenticated-orcid":false,"given":"Shuting","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital of Soochow 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