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Recent evidence suggests that there is some frequency specificity in the effects of tACS on motor function within the midgamma band (60\u201390\u2009Hz). The purpose of this study was to examine the effect of different tACS frequencies within the gamma band on the neuroplastic response to iTBS. Seventeen healthy young adults performed four experimental sessions, where iTBS was combined with different tACS conditions (60, 75 and 90\u2009Hz, sham) over M1 using a tACS\u2010iTBS costimulation approach. Motor evoked potential (MEP) amplitude and short\u2010interval intracortical inhibition (SICI) were assessed from a hand muscle before and after the intervention using transcranial magnetic stimulation with posterior\u2013anterior (PA) and anterior\u2013posterior (AP) coil orientations. Gamma tACS\u2010iTBS costimulation increased PA and AP MEPs when gamma tACS was applied at 90\u2009Hz, but not at 75 or 60\u2009Hz, compared with sham tACS. PA and AP SICI was reduced by tACS\u2010iTBS costimulation, but this was not influenced by gamma tACS frequency. Gamma tACS can increase LTP\u2010like plasticity when combined with iTBS over M1, with the largest effect observed when tACS was applied at higher gamma frequencies. The functional relevance of targeting higher gamma frequencies within different brain areas and study populations remains to be determined.<\/jats:p>","DOI":"10.1111\/ejn.70018","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:59:17Z","timestamp":1739249957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gamma Transcranial Alternating Current Stimulation Has Frequency\u2010Dependent Effects on Human Motor Cortex Plasticity Induced by Theta\u2010Burst Stimulation"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-9796","authenticated-orcid":false,"given":"Wei\u2010Yeh","family":"Liao","sequence":"first","affiliation":[{"name":"Discipline of Physiology, School of Biomedicine University of Adelaide  Adelaide 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