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The literature is mixed and the most supported explanation is the reduction of dopaminergic treatment. Yet a body of clinical and experimental evidences suggest that STN\u2010DBS itself can also promote apathy in certain patients. However, the parameters accounting for apathy heterogeneity in stimulated patients along with the mechanisms underlying apathy induced by STN\u2010DBS remain to be investigated. Whether bilateral and unilateral STN\u2010DBS have the same influence on apathy is for instance unknown. We previously and separately showed in patients and rodents that bilateral STN\u2010DBS can promote apathy per se. Here, we compare the effect of bilateral\n                    <jats:italic>versus<\/jats:italic>\n                    unilateral STN\u2010DBS both in patients and in rodents. We conducted a clinical follow\u2010up of patients with Parkinson's disease undergoing unilateral or bilateral STN\u2010DBS and assessing apathy 3\u2009months before and after STN\u2010DBS. In parallel, we applied chronic and uninterrupted unilateral or bilateral DBS in rodents and extract longitudinal motivational changes with a battery of behavioural tests. While bilateral STN\u2010DBS promotes apathy in patients and induces a loss of motivation in rodents, we found that unilateral STN\u2010DBS did not exert such an effect both in patients and in rats. These data show that bilateral but not unilateral STN\u2010DBS promotes apathy. This not only substantiate the induction of neuropsychiatric effects by STN\u2010DBS but also suggest that this might be circumvented if STN\u2010DBS is applied unilaterally instead of bilaterally.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70019","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:25:26Z","timestamp":1739845526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-2751","authenticated-orcid":false,"given":"Yvan\u00a0M.","family":"Vachez","sequence":"first","affiliation":[{"name":"Univ. 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