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Although previous studies have examined the effects of LC stimulation on single\u2010unit sensory neurons, their impact on somatosensory evoked potentials (SEPs) and their temporal variations, as well as the specific roles of NA receptors, remain unclear. Herein, we investigated how SEPs are modulated by tonic LC stimulation at physiological frequencies (0.1, 1 and 4\u2009Hz) and identified the receptors involved in these changes. Forepaw stimulation\u2010induced amplitudes in SEP were enhanced in response to 1\u2009Hz stimulation of the LC but not in response to 0.1 and 4\u2009Hz stimulation. Interestingly, the enhancement of SEPs after LC stimulation persisted for tens of minutes following the cessation of stimulation. Optical imaging using a voltage\u2010sensitive dye showed an increase in the depolarizing response in the somatosensory cortex after 1\u2009Hz stimulation. Prazosin (\u03b11 receptor antagonist) and propranolol (\u03b2 receptor antagonist) inhibited SEP enhancement following 1\u2009Hz LC stimulation, whereas yohimbine (\u03b12 receptor antagonist) had no effect. This suggests that the enhancement in SEP observed is primarily mediated by the activation of cortical excitatory \u03b11 and \u03b2 receptors. These findings provide insight into the impact of the NA system on sensory information processing and the pathophysiology of sensory disorders related to the disruption of the NA system.<\/jats:p>","DOI":"10.1111\/ejn.70020","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T21:50:22Z","timestamp":1739397022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tonic Electrical Stimulation of the Locus Coeruleus Enhances Cortical Sensory\u2010Evoked Responses via Noradrenaline \u03b11 and \u03b2 Receptors"],"prefix":"10.1111","volume":"61","author":[{"given":"Takanobu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Graduate School Niigata University of Health and Welfare  Niigata Japan"},{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare  Niigata Japan"},{"name":"Department of System Pathology for Neurological 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