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These pathological Tau aggregates define tauopathies such as Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ), as well as the pathological sequelae following traumatic brain injury (TBI), stroke and spinal cord injury (SCI). We hypothesized that differential applications of extremely low\u2010frequency and low\u2010intensity electromagnetic field (ELF\u2010EMF) will change microtubule function. To examine our hypothesis, we pre\u2010applied ELF\u2010EMF to a neuroblastoma neuronal cell line later exposed to 4 h of zinc intoxication, modelling Tau\u2010microtubule dissociation. ELF\u2010EMF (40\u2009Hz and 1\u2009G; multiple exposure schedules) enhanced microtubule dynamics and increased Tau\u2010microtubule interaction in the face of zinc toxicity. Complementing these preconditioning neuroprotective effects, concomitant 1 h treatment protocols comparing 3.9 or 40\u2009Hz and 1\u2009G exposure, indicated effects on Tau phosphorylation accentuated with 40\u2009Hz and reduction in beta tubulin isotypes, depending on electromagnetic frequencies, most pronounced at 3.9\u2009Hz. Our results discovered ELF\u2010EMF modulation on the microtubule cytoskeleton essential for brain health.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70023","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T22:50:36Z","timestamp":1739919036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Extremely Low\u2010Frequency and Low\u2010Intensity Electromagnetic Field Technology (ELF\u2010EMF) Sculpts Microtubules"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4988-4778","authenticated-orcid":false,"given":"Alexandra","family":"Lobyntseva","sequence":"first","affiliation":[{"name":"The Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical and Health Sciences, Sagol School of Neuroscience and Adams Super Center for Brain Studies Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"Ganaiem","sequence":"additional","affiliation":[{"name":"The Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical and Health Sciences, Sagol School of Neuroscience and Adams Super Center for Brain Studies Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-7127","authenticated-orcid":false,"given":"Yanina","family":"Ivashko\u2010Pachima","sequence":"additional","affiliation":[{"name":"The Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical and Health Sciences, Sagol School of Neuroscience and Adams Super Center for Brain Studies Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-4068","authenticated-orcid":false,"given":"Colin\u00a0J.","family":"Barnstable","sequence":"additional","affiliation":[{"name":"Department of Neural and Behavioral Sciences Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-617X","authenticated-orcid":false,"given":"Batsheva","family":"Weisinger","sequence":"additional","affiliation":[{"name":"BrainQ Technologies, Ltd.  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