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Ca2+\/calmodulin\u2010dependent protein kinase II (CaMKII) is a serine\/threonine\u2010specific protein kinase highly enriched in the hippocampal formation, where it acts as a memory\u2010relevant calcium effector. We found that, in rats, training in an ORM inducing learning task rapidly increased CaMKII autophosphorylation in the CA1 region of the dorsal hippocampus. Moreover, early post\u2010acquisition intra\u2010dorsal CA1 injection of the substrate\u2010competitive CaMKII inhibitor AIP impaired long\u2010term ORM without affecting short\u2010term ORM or previously consolidated ORMs. The amnesia induced by AIP was replicated by the calmodulin\u2010competitive CaMKII inhibitor KN93, but not by the inactive analogues of either KN93 or AIP. Notably, these effects occurred regardless of the subject's sex and age or the time of day when learning took place. Together, our findings indicate that hippocampal CaMKII activity is necessary shortly after training for the normal consolidation of ORM.<\/jats:p>","DOI":"10.1111\/ejn.70049","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:50:13Z","timestamp":1741711813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hippocampal CaMKII Regulates the Consolidation of Recognition Memory"],"prefix":"10.1111","volume":"61","author":[{"given":"Janine\u00a0I.","family":"Rossato","sequence":"first","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute and Department of Physiology and Behavior Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Carolina","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Memory Research Laboratory \u2010 Brain Institute and Department of 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