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Prior to motor symptoms onset, alterations, and dysfunctions in the corticostriatal projections have been described along with cognitive deficits, but the sequence of early alterations of brain circuits is largely unknown. There is thus a crucial need to identify early alterations that precede symptoms and that could be used as potential early disease markers. Using an HD knock\u2010in mouse model (Hdh\n                    <jats:sup>CAG140\/+<\/jats:sup>\n                    ) that recapitulates the human genetic alterations and that shows a late and progressive appearance of anatomical and behavioral deficits, we identified early alterations in the motor learning abilities of young mice, long before any motor coordination dysfunctions. In parallel, ex\u00a0vivo two\u2010photon calcium recordings revealed that young HD mice have altered basal activity patterns in both the dorsomedial and dorsolateral parts of the striatum. In addition, although wild\u2010type mice display specific reorganization of the activity upon motor training, network alterations present in the basal state of non\u2010trained mice are not affected by motor training of HD mice. Our results thus identify early behavioral deficits and network alterations that could serve as early markers of the disease.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70056","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:09:41Z","timestamp":1741824581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Alterations of Motor Learning and Corticostriatal Network Activity in a Huntington's Disease Mouse Model"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-6266","authenticated-orcid":false,"given":"N.","family":"Badreddine","sequence":"first","affiliation":[{"name":"INMED, Aix\u2010Marseille University, INSERM U1249  Marseille France"},{"name":"University Grenoble Alpes, INSERM U1216, CHU Grenoble Alpes, CNRS, Grenoble Institut Neurosciences  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Appaix","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, INSERM U1216, CHU Grenoble Alpes, CNRS, Grenoble Institut Neurosciences  Grenoble France"},{"name":"University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Becq","sequence":"additional","affiliation":[{"name":"Laboratoire Gipsa\u2010Lab, University Grenoble Alpes, UMR 5216 CNRS, Grenoble\u2010INP  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Achard","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, UMR 5224 CNRS, Laboratoire Jean Kuntzmann  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Saudou","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, INSERM U1216, CHU Grenoble Alpes, CNRS, Grenoble Institut Neurosciences  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1453-7784","authenticated-orcid":false,"given":"E.","family":"Fino","sequence":"additional","affiliation":[{"name":"INMED, Aix\u2010Marseille University, INSERM U1249  Marseille France"},{"name":"University Grenoble Alpes, INSERM U1216, CHU Grenoble Alpes, CNRS, Grenoble Institut Neurosciences  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38744"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110623"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554\u201307.2007"},{"key":"e_1_2_10_5_1","unstructured":"Becq G. 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