{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:26:11Z","timestamp":1778426771886,"version":"3.51.4"},"reference-count":80,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008688","name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["FIDSC2018\/77 to CV"],"award-info":[{"award-number":["FIDSC2018\/77 to CV"]}],"id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["1007670 to GA"],"award-info":[{"award-number":["1007670 to GA"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["1015394 to LOP"],"award-info":[{"award-number":["1015394 to LOP"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["621336 to CS"],"award-info":[{"award-number":["621336 to CS"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["INFR\u20102016\u201001\u2010268247 to CV"],"award-info":[{"award-number":["INFR\u20102016\u201001\u2010268247 to CV"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic stress increases susceptibility to anxiety and depression disorders, recurrent and common psychiatric conditions. Current antidepressant medications have varying degrees of efficacy and often have multiple side effects limiting treatment adherence. Physical exercise has beneficial effects on stress\u2010related mental disorders. However, the underlying mechanisms are unclear. Dentate gyrus granule cells (GCs) excitability may mediate stress resilience. Here, we expose young adult C57Bl6 mice to chronic restraint stress (CRS) for 14\u2009days followed by 30\u2009days of running treatment. Behavioural evaluation before and after treatment showed that the behavioural alterations elicited by CRS were mitigated by running. Next, we evaluated serotonergic modulation of GC excitability, as a potential mechanism underlying running\u2010induced stress resilience. Electrophysiological recordings indicate that CRS alters serotonergic modulation of GC excitability. Utilising (S)\u2010WAY 100135 and Tropisetron, antagonists of 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    receptors respectively, we show that running recovers 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor activity lost by CRS. Additionally, running promotes the indirect modulation of GCs through 5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    receptor activation. Thus, 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5\u2010HT\n                    <jats:sub>3<\/jats:sub>\n                    receptors may be potential targets for the treatment of stress\u2010related psychiatric disorders.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70084","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T22:49:45Z","timestamp":1743547785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Running Reverses Chronic Stress\u2010Induced Changes in Serotonergic Modulation of Hippocampal Granule Cells and Altered Behavioural Responses"],"prefix":"10.1111","volume":"61","author":[{"given":"Carmen","family":"Soto","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenesis and Neuroplasticity. Department of Physiology, Biophysics and Neuroscience Centro de Investigacion y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazaro\u00a0P.","family":"Orihuela","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenesis and Neuroplasticity. Department of Physiology, Biophysics and Neuroscience Centro de Investigacion y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grego","family":"Apostol","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenesis and Neuroplasticity. Department of Physiology, Biophysics and Neuroscience Centro de Investigacion y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-1091","authenticated-orcid":false,"given":"Carmen","family":"Vivar","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenesis and Neuroplasticity. Department of Physiology, Biophysics and Neuroscience Centro de Investigacion y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.10.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00296.2010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0262-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2430334"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016862"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.223669"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03727-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.08.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00201"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.10.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.41.1.c"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)63014-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.12.025"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22557"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.11.031"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23520"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01626-3"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0674-18.2018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00861.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20758"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2013.28.4.288"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41539-022-00133-y"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90598-X"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.060"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.040"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11010009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.5.1935"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn849"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20754"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5717\/jenb.2014.18.1.97"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00088"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.153"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22604"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2023.1124112"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.021"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.105"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0733-19.2019"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4086"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.171"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(94)90134-1"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-09-03157.1997"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01754-0"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00181-9"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901960110"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.137027"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8716"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.05.007"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020469"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08378.2001"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00971.2004"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.52"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21810"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4116"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.08.009"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.01.009"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22649"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5352-12.2013"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20751"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0794-12.2012"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53624-1"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12093"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106195"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.09.040"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0038"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.11.023"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02598-6"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.10.010"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00619.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.031"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2012_220"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00017.2017"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2787-20.2021"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.01.006"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.08.001"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4193-12.2013"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01571-9"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113629"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)00225-4"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.08.050"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T09:12:50Z","timestamp":1748855570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ejn.70084"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70084","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70084\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70084\/v2\/response1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70084"}}