{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:47:59Z","timestamp":1791575279870,"version":"4.3.4"},"reference-count":117,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["10001C_197480"],"award-info":[{"award-number":["10001C_197480"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The growing prevalence of physical and neurological disorders linked to aging poses significant challenges for society. Many of these disorders are closely linked to changes in brain structure and function, highlighting the importance of identifying protective factors that can preserve brain structure in later life and mitigate age\u2010related decline. Physical activity (PA) is consistently linked to physical health and was found to mitigate age\u2010related disorders. However, its effects on markers of brain aging remain inconclusive, partly due to reliance on underpowered studies and self\u2010reported data. We investigated the effects of accelerometer\u2010measured PA and physical fitness on BrainAGE, a machine\u2010learning\u2010derived marker of brain aging, in a large UK Biobank cohort. Using cortical and subcortical neuroimaging\u2010derived features, a BrainAGE model was trained on 21,442 participants (mean absolute error: 3.75\u2009years) and applied to predict BrainAGE for an independent sample of 10,874 participants. Accelerometer\u2010measured moderate\u2010intensity PA, but not self\u2010reported PA, was associated with decelerated brain aging, indicated by a negative BrainAGE. Further, higher hand grip strength, along with lower body mass index (BMI), diastolic blood pressure (DBP), and resting heart rate, was linked to decelerated aging. These fitness measures impacted BrainAGE independently of PA. Additionally, fitness partially accounted for the relationship between PA and BrainAGE. Specifically, BMI, DBP, and resting heart rate showed a significant mediating effect, while grip strength did not. These findings highlight the interplay between PA and fitness in maintaining brain health and provide valuable insights for neuroscience and preventive health measures.<\/jats:p>","DOI":"10.1111\/ejn.70085","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T07:42:27Z","timestamp":1744789347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maintaining Brain Health: The Impact of Physical Activity and Fitness on the Aging Brain\u2014A UK Biobank Study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2310-7033","authenticated-orcid":false,"given":"Hanna","family":"Hoogen","sequence":"first","affiliation":[{"name":"Department of Psychology University of Zurich  Zurich Switzerland"},{"name":"Faculty of Psychology &amp; Neuroscience Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-7396","authenticated-orcid":false,"given":"Bruno","family":"Hebling\u00a0Vieira","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-9471","authenticated-orcid":false,"given":"Nicolas","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.034"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103600"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(88)90025-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/BJSM.2008.050906"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.06.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.04.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08983"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010020\u201002184\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.913s"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S194543"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2013011843"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"Brown B. J.deFrutos Lucs T.Porter et\u00a0al.2022.Non\u2010modifiable Factors as Moderators of the Relationship Between Physical Activity and Brain Volume: A Cross\u2010Sectional UK Biobank Study.medRxiv.https:\/\/doi.org\/10.1101\/2022.01.01.22268616.","DOI":"10.1101\/2022.01.01.22268616"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN\u20102015\u2013010038"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0036345"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM9040914"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"Cheval B. L.Darrous K. W.Choi et\u00a0al.2022.Accelerometer\u2010Measured Physical Activity and Cognitive Functioning: A Mendelian Randomization Study. bioRxiv 2020.10.16.342675.https:\/\/doi.org\/10.1101\/2020.10.16.342675.","DOI":"10.1101\/2020.10.16.342675"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.10.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.059"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.62"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00429\u2010017\u20101505\u20100\/FIGURES\/3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102229"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169649"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBR.2020.113061"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2015.01.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.034"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/HIPO.20547"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f88359"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(02)00569\u2010x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1024\/1662\u20139647\/a000074"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00789"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00090"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2014.00094\/ABSTRACT"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/AJE\/KWX246"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2014.08.018"},{"key":"e_1_2_10_40_1","unstructured":"Geneva World Health Organization.2010.Global Recommendations on Physical Activity for Health(Tech. Rep.)."},{"key":"e_1_2_10_41_1","unstructured":"Geneva World Health Organization.2020.WHO Guidelines on Physical Activity and Sedentary Behaviour."},{"key":"e_1_2_10_42_1","unstructured":"Geneva World Health Organization.2022.Global Status Report on Physical Activity 2022.https:\/\/www.who.int\/teams\/health\u2010promotion\/physical\u2010activity\/global\u2010status\u2010report\u2010on\u2010physical\u2010activity\u20102022."},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0285272"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1469\u20138986.2008.00676.X"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AMEPRE.2004.07.006"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9175806"},{"key":"e_1_2_10_47_1","unstructured":"He W. D.Goodkind andP.Kowal.2016.An Aging World: 2015 International Population Reports (tech. rep.). Washington D.C."},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YNIRP.2021.100011"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/17477160802596171"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000289"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2298"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21113"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11357\u2010023\u201000734\u20104"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANETWORKOPEN.2023.54285"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010022\u201002490\u20102"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2016.00336\/BIBTEX"},{"key":"e_1_2_10_57_1","volume-title":"Human Brain Mapping","author":"Kalc P.","year":"2024"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CARDIORES.2005.03.010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201022477\u20106"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.06.009"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.626677"},{"key":"e_1_2_10_62_1","unstructured":"Langan M. A.2008.A Contemporary History of the Origins and Development of UK Biobank 1998\u20132005.https:\/\/eleanor.lib.gla.ac.uk\/record=b2617598."},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058162"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/OXFORDJOURNALS.AJE.A010205"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PSCYCHRESNS.2021.111270"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2022.21680"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa250"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.24588"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110471"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000037"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/00336297.2001.10491751"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/GLAC209"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/S21103326"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201054267\u2010y"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCHGER.2018.05.009"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4393"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.31887\/dcns.2013.15.1\/fmora"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.119947"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24899"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.36.3.162"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/OBY.2003.154"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001504\u2010200503000\u201000013"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101871"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002172\u20105"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.04.001"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105868\u20105\u201056\/FIGURES\/8"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20132236(92)90051\u20139"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/AGEING\/AFY188"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1689"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00429\u2010017\u20101414\u20102\/TABLES\/4"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2016.07.010"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.2000.11082780\/asset\/\/cms\/asset\/b63ef4b8\u2010ac80\u20104eb8\u20109e0f\u2010d182b64bcd6a\/02701367.2000.11082780.fp.png"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102767"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2018.1555904"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0293555"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2015.9617"},{"key":"e_1_2_10_98_1","unstructured":"Sjostrom M. B. E.Ainsworth A.Bauman F. C.Bull C. R.Hamilton\u2010Craig andJ. F.Sallis.2005.Guidelines for Data Processing and Analysis Concerning the International Physical Activity Questionnaire."},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002415"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.01.014"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.09.018"},{"key":"e_1_2_10_102_1","unstructured":"Tian Y. E. V.Cropley A. B.Maier N. T.Lautenschlager M.Breakspear andA.Zalesky.2022.Biological Aging of Human Body and Brain Systems.medRxiv.https:\/\/www.medrxiv.org\/content\/10.1101\/2022.09.03.22279337v1.abstract."},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JSC.0000395736.42557.BC"},{"key":"e_1_2_10_104_1","unstructured":"UK Biobank.2011a.Blood Pressure Measurement Documentation.https:\/\/biobank.ndph.ox.ac.uk\/ukb\/refer.cgi?id=100225."},{"key":"e_1_2_10_105_1","unstructured":"UK Biobank.2011b.Grip Strength Measurement.https:\/\/biobank.ndph.ox.ac.uk\/ukb\/refer.cgi?id=100232."},{"key":"e_1_2_10_106_1","unstructured":"UK Biobank.2020.Brain Imaging Documentation.https:\/\/biobank.ndph.ox.ac.uk\/ukb\/refer.cgi?id=1977."},{"key":"e_1_2_10_107_1","unstructured":"UK Biobank.2022.Sex Documentation.https:\/\/biobank.ndph.ox.ac.uk\/ukb\/field.cgi?id=31."},{"key":"e_1_2_10_108_1","unstructured":"UK Biobank.2024.Qualification Documentation.https:\/\/biobank.ndph.ox.ac.uk\/ukb\/field.cgi?id=6138."},{"key":"e_1_2_10_109_1","unstructured":"United Nations.2019.World Population Ageing 2019: Highlights.http:\/\/link.springer.com\/chapter\/10.1007\/978\u201094\u2010007\u20105204\u201076."},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HJR.0000161551.73095.9C"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MHPA.2014.01.001"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.044"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0b013e31825dabb8"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1615\/jlongtermeffmedimplants.v16.i2.90"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2001.0909"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YNIRP.2022.100146"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.2.010506.092044"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2023.103319"}],"updated-by":[{"DOI":"10.1111\/ejn.70312","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000}}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:28:08Z","timestamp":1762932488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":117,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ejn.70085"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70085","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70085\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70085\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70085\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70085\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70085\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70085\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70085"}}