{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:59Z","timestamp":1772160239005,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Magnetic resonance imaging (MRI) is pivotal to the evaluation of cerebral atrophy in Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ). Although there are several scoring systems to identify atrophy in areas of interest, the possibility of having a simple and practical scale focused on evaluating parietal atrophy by MRI in a single axial slice in T2\u2010Flair sequencing would be highly advantageous. We develop and validate the Mimenza\u2013Aguilar\u2013Herrera (MAH) visual scale to determine the degree of modified parietal atrophy by analyzing the posterior cingulate gyrus in an MRI axial slice in T2 weighted sequencing in individuals with early\n                    <jats:sc>AD<\/jats:sc>\n                    . Patients with\n                    <jats:sc>AD<\/jats:sc>\n                    , mild cognitive impairment, and other dementias were included. Interrater and intrarater concordance was analyzed with Cohen's kappa. ROC analysis was used to determine sensitivity\/specificity. The relationship between medial parietal atrophy (MPA) and the MMSE and MoCA scores, age, educational level, and sex was determined by linear regression. Interrater concordance in the MPA\u2010MAH was moderate, 0.83 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). The area under the curve in the mild\n                    <jats:sc>AD<\/jats:sc>\n                    group was 0.74, with a sensitivity of 71.67% and a specificity of 76.19% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). An association was detected between a MPA score &gt;\u20091 [OR 5.1 (95% CI: 2\u201312.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001)], MMSE &lt;\u200924 pts, [OR 4.5 (95% CI: 1.2\u201317.6,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026)], and MoCA &lt;\u200924 pts, after adjusting for age and sex. The MAH scale proved useful in diagnosing early\n                    <jats:sc>AD<\/jats:sc>\n                    , with comparable performance to validated scales such as Koedam's and Scheltens'. This instrument could allow a quick and easy evaluation.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70095","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T01:22:29Z","timestamp":1743470549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Construction and Validation of the Modified Parietal Atrophy Index by Magnetic Resonance Imaging in Patients With Alzheimer's Disease in a Memory Clinic"],"prefix":"10.1111","volume":"61","author":[{"given":"Alberto\u00a0Jos\u00e9","family":"Mimenza\u2010Alvarado","sequence":"first","affiliation":[{"name":"Department of Geriatrics INCMNSZ  Mexico City Mexico"},{"name":"Fellow in Neurological\u2010Geriatrics INCMNSZ  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0Alberto","family":"Herrera\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Fellow in Neurological\u2010Geriatrics INCMNSZ  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnatan","family":"Rubalcava\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Radiology INCMNSZ  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle\u00a0Yanieska","family":"Gonz\u00e1lez\u2010Putoy","sequence":"additional","affiliation":[{"name":"Department of Radiology INCMNSZ  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-1408","authenticated-orcid":false,"given":"Juan\u00a0de\u00a0Dios","family":"Rodr\u00edguez\u2010Callejas","sequence":"additional","affiliation":[{"name":"Department of Geriatrics INCMNSZ  Mexico City Mexico"},{"name":"Centro de Investigaci\u00f3n sobre el Envejecimiento\u2010CINVESTAV sede sur  M\u00e9xico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara\u00a0Gloria","family":"Aguilar\u2010Navarro","sequence":"additional","affiliation":[{"name":"Department of Geriatrics INCMNSZ  Mexico City Mexico"},{"name":"Fellow in Neurological\u2010Geriatrics INCMNSZ  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcp.2017.05.003"},{"key":"e_1_2_11_3_1","unstructured":"American Psychiatric Association Publishing.2022. \u201cNeurocognitive Disorders Supplement Updated Excerpts for Delirium Codes Major and Mild Neurocognitive Disorders\u201d."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.11.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00272"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102013\u2010306948"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.96"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010310090"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137307"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.1290"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_11_13_1","unstructured":"Miguel Guti\u00e9rrez\u2010Robledo L. 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L.Arrieta\u2010Cruz M.Guti\u00e9rrez andR.Direcci\u00f3n.2015. \u201cDemencias en M\u00e9xico: La Necesidad de un Plan de Acci\u00f3n GACETA M\u00c9DICA DE M\u00c9XICO SIMPOSIO Correspondencia.\u201dwww.anmm.org.mx."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41983\u2010023\u201000649\u2010z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/21.4.556"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26146"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205017666200807193957"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010018\u20100390\u2010y"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051\u20105960\u20101\u201030"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010019\u20101072\u20108"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T09:13:20Z","timestamp":1748855600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ejn.70095"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70095","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70095\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70095\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70095\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70095\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70095\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70095\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2024-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70095"}}