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Natural killer (NK) cells are also components of innate immunity, whose role in\n                    <jats:sc>AD<\/jats:sc>\n                    pathogenesis has been sporadically investigated and often conflicting results have been reported. Recent clinical trial has suggested the potential beneficial effects of\n                    <jats:sc>AD<\/jats:sc>\n                    immunotherapy based on ex\u00a0vivo\u2013expanded, genetically unmodified, NK cells. This has led to increased interest in understanding the function of these cells in the central nervous system in both physiological and pathological contexts such as\n                    <jats:sc>AD<\/jats:sc>\n                    . Considering that\n                    <jats:sc>AD<\/jats:sc>\n                    is predominantly a disease of the elderly population, in this review, we summarized the current state of knowledge on the physiological changes that occur in the NK cell compartment during the normal aging process and the pathophysiological alterations that occur throughout the\n                    <jats:sc>AD<\/jats:sc>\n                    continuum that could potentially explain the therapeutic efficacy of these cells.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70096","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:47:12Z","timestamp":1744271232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Natural Killer Cells in Alzheimer's Disease: From Foe to 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