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The primary histopathological features underlying these conditions include the cumulation of pathological protein aggregates, chronic inflammation, and neuronal cell death. Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ) and Parkinson's disease (PD) are prominent examples of neurodegenerative diseases (NDDs). As of 2023, over 65 million people worldwide are affected by\n                    <jats:sc>AD<\/jats:sc>\n                    and PD, with the prevalence of these conditions steadily increasing over time. Interestingly, there are no effective therapies available to halt or slow NDD progression. Most approved treatments are focused on symptom management and are often associated with substantial side effects. Given these limitations, the development of novel therapeutic approaches targeting the molecular mechanisms underlying these disorders is essential. Notably, RNA\u2010based therapeutics have recently emerged as a potential therapeutic approach for managing various neurological diseases, offering the potential for innovative molecular interventions in NDD. In this review, we have discussed the pathogenic role of various protein aggregates in NDD and highlighted emerging RNA\u2010based strategies aimed at targeting these pathological proteins.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70110","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T09:38:51Z","timestamp":1744796331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["RNA\u2010Based Therapies for Neurodegenerative Diseases Targeting Pathogenic Proteins"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-8158","authenticated-orcid":false,"given":"Syed\u00a0Arman","family":"Rabbani","sequence":"first","affiliation":[{"name":"RAK College of Pharmacy RAK Medical and Health Sciences University  Ras Al Khaimah 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