{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:58:06Z","timestamp":1791863886723,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This sham\u2010controlled animal study aimed to investigate the effects of melatonin and methylprednisolone combination on motor function, nerve conduction and histopathological and biochemical findings in rats with sciatic nerve crush injury. Forty\u2010eight male Sprague\u2013Dawley rats were divided into 6 groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098): CT: control, VEH: sciatic nerve injury, LMP: 15\u2010mg\/kg methylprednisolone, high\u2010dose methylprednisolone (HMP): 30\u2010mg\/kg methylprednisolone, MEL: 15\u2010mg\/kg melatonin, MMP: 15\u2010mg\/kg methylprednisolone+15\u2010mg\/kg melatonin. The rats were evaluated with Sciatic Functional Index (SFI), nerve conduction study, interleukin\u20101\u03b2\n                    <jats:bold>(<\/jats:bold>\n                    IL\u20101\u00df), nerve growth factor (NGF), total antioxidant status (TAS), total oxidant status (TOS) and histopathological scores. There were no significant intergroup differences in baseline tests. SFI significantly improved in all treated groups with no significant intergroup differences. Motor amplitude improved most in MMP, LMP and MEL, respectively. Nerve conduction velocity significantly improved in MMP compared to VEH. There were no significant intergroup differences regarding serum NGF, TAS and TOS. Tissue NGF levels were higher in LMP, HMP and MEL. IL\u20101\u00df levels were significantly lower in CT and MMP. Tissue oxidative stress levels were significantly lower in treated groups compared to VEH, with no significant difference among them. MMP showed greater histopathological improvement. Melatonin combination therapy in sciatic nerve crush injury provided adequate functional improvement, superior electrophysiological and histopathological recovery compared to high\u2010dose methylprednisolone and exhibited better anti\u2010inflammatory activity through IL\u20101\u00df.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70116","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:04:11Z","timestamp":1745553851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melatonin and Methylprednisolone Combination Ameliorates Inflammation and Enhances Recovery After Sciatic Nerve Crush Injury"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-8331","authenticated-orcid":false,"given":"G\u00f6k\u00e7enur","family":"Yal\u00e7\u0131n","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Marmara University Training and Research Hospital  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-9547","authenticated-orcid":false,"given":"Ba\u015fak\u00a0Bilir","family":"Kaya","sequence":"additional","affiliation":[{"name":"Ministry of Health Erenk\u00f6y Physical Medicine and Rehabilitation Hospital  Istanbul Turkiye"},{"name":"University of Health Sciences  Istanbul Turkiye"},{"name":"Department of Physical Medicine and Rehabilitation Sultan 2. 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