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However, the relationship between subtle differences in lower extremity kinematics and concurrent brain activity during motor tasks is mainly unknown. Additionally, there is limited information regarding the consistency of brain activation measures during a lower extremity motor task. The current study evaluated the within\u2010session reliability of knee joint kinematics and brain activation during a supine bilateral leg press task using functional magnetic resonance imaging in 67 adolescent female athletes. Knee joint kinematics, including the number of leg press repetitions (cycles), as well as sagittal and frontal ranges of motion and their standard deviations, were analysed with concurrent blood\u2010oxygen\u2010level\u2010dependent signals to explore the relationship between these biomechanical variables and brain activation. The results showed good reliability for knee joint kinematics and moderate reliability for brain activation in sensorimotor regions (precentral and postcentral gyri, supplementary motor cortex, brainstem, and anterior cerebellum lobules). Greater knee sagittal range of motion correlated with increased activation in motor planning and sensory integration regions, such as the dorsal striatum and lateral occipital cortex. These findings establish the supine bilateral leg press task as a reliable paradigm for investigating lower extremity motor control, providing insights into the neural mechanisms underlying movement variability. Additionally, brain regions exhibiting reliable activation could serve as valuable regions of interest for future investigations, enhancing the statistical power and reproducibility of research findings.<\/jats:p>","DOI":"10.1111\/ejn.70126","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T19:56:17Z","timestamp":1746042977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reliability of Brain Activity During a Supine Bilateral Leg Press and Association With Concurrent 3D Knee Joint Biomechanics"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-3452","authenticated-orcid":false,"given":"HoWon","family":"Kim","sequence":"first","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute Ohio University  Athens Ohio USA"},{"name":"Translational Biomedical Sciences Program, School of Rehabilitation and Communication Sciences College of Health Sciences and Professions, Ohio University  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor\u00a0M.","family":"Zuleger","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Veterans Affairs Atlanta VA Medical Center  Decatur Georgia USA"},{"name":"Emory Sports Medicine Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis\u00a0B.","family":"Slutsky\u2010Ganesh","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Emory Sports Medicine Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Anand","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayla\u00a0M.","family":"Warren","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Emory Sports Medicine Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed\u00a0A.","family":"Diekfuss","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Veterans Affairs Atlanta VA Medical Center  Decatur Georgia USA"},{"name":"Emory Sports Medicine Center  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan\u00a0R.","family":"Schlink","sequence":"additional","affiliation":[{"name":"Battelle Memorial Institute  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin\u00a0L.","family":"Rush","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute Ohio University  Athens Ohio USA"},{"name":"Division of Physical Therapy, School of Rehabilitation and Communication Sciences, College of Health Sciences and Professions Ohio University  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet\u00a0E.","family":"Simon","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute Ohio University  Athens Ohio USA"},{"name":"Division of Athletic Training, School of Applied Health Sciences and Wellness, College of Health Sciences and Professions Ohio University  Athens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory\u00a0D.","family":"Myer","sequence":"additional","affiliation":[{"name":"Emory Sports Performance And Research Center (SPARC)  Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Wallace H. 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