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Current treatments primarily address symptoms, yet nano\u2010chaperones can potentially intervene at the molecular level by mimicking natural chaperone proteins to prevent or reverse amyloid aggregation. In\n                    <jats:sc>AD<\/jats:sc>\n                    , nano\u2010chaperones target amyloid\u2010beta (A\u03b2) peptides, reducing neurotoxicity and preserving neuronal function, while in T2DM, they inhibit islet amyloid polypeptide (IAPP) aggregation, alleviating cytotoxic stress on pancreatic \u03b2\u2010cells. These nanoparticles exhibit a dual capacity for cellular penetration and selectivity in interacting with misfolded proteins, showing promise in mitigating the shared amyloidogenic pathways of both diseases. Preclinical studies have demonstrated significant reductions in amyloid toxicity with potential applications in crossing the blood\u2013brain barrier (BBB) to enhance central nervous system (CNS) delivery. Nano\u2010chaperones transformative role in developing multi\u2010targeted precision therapies for complex diseases is highlighted, underscoring their capacity to modulate disease progression through targeted biomimetic interactions. Nano\u2010chaperone designs for clinical application focus on enhancing therapeutic efficacy and safety. This innovative approach may redefine treatment paradigms for amyloid\u2010related diseases, offering a new frontier in personalized medicine.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70142","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T03:05:07Z","timestamp":1747623907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nano\u2010Chaperones: Bridging Therapeutics for Amyloid Aggregation in Alzheimer's Disease and Type\u20102 Diabetes Mellitus"],"prefix":"10.1111","volume":"61","author":[{"given":"Faiza","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeba","family":"Khanam","sequence":"additional","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravej","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science and Humanities Prince Sattam bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamer","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science and Humanities Prince Sattam bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-2562","authenticated-orcid":false,"given":"Salman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snober\u00a0S.","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01167.x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135761"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13389"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01163-7"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051195"},{"key":"e_1_2_14_7_1","article-title":"Amyloid Disassembly: What Can We Learn From Chaperones?","volume":"10","author":"Almeida Z. 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