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This article explores the involvement of protein kinases in these disorders, focusing on their contributions to disease mechanisms, potential as therapeutic targets and challenges in developing effective treatments. In Alzheimer's disease, kinases such as CDK5, GSK3\u03b2 and MARK4 are implicated in tau hyperphosphorylation and the formation of neurofibrillary tangles. Kinases also regulate amyloid\u2010\u03b2 processing and plaque formation. In Parkinson's disease, LRRK2, PINK1 and other kinases contribute to \u03b1\u2010synuclein pathology, mitochondrial dysfunction and neuroinflammation. LRRK2 inhibitors and PROTACs have shown promise in preclinical models. Huntington's disease involves altered kinase activity, with CK2, GSK3 and MAPK pathways influencing mutant huntingtin toxicity and aggregation. Kinases are also implicated in less common neurodegenerative diseases, such as ALS and spinocerebellar ataxias. Despite the therapeutic potential of targeting kinases, challenges remain, including the complexity of kinase networks, blood\u2013brain barrier permeability and the lack of robust biomarkers. Emerging technologies, such as covalent inhibitors, targeted protein degradation and combination therapies, offer new avenues for addressing these challenges and developing more effective treatments for neurodegenerative diseases.<\/jats:p>","DOI":"10.1111\/ejn.70156","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:58:59Z","timestamp":1749020339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Kinases in Neurodegenerative Diseases: From Pathogenesis to Treatment"],"prefix":"10.1111","volume":"61","author":[{"given":"Alkusha","family":"Naim","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar\u00a0Mahmood","family":"Farooqui","sequence":"additional","affiliation":[{"name":"Integral Institute of Medical Sciences and Research Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Badruddeen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u00a0Irfan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juber","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2094-9435","authenticated-orcid":false,"given":"Anas","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"},{"name":"School of Pharmaceutical Sciences, Faculty of Pharmacy Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105090"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30468"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102548"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010025\u201001554\u20100"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230828"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002201\u2010z"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1831\u201007.2007"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176816"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102247"},{"key":"e_1_2_16_11_1","unstructured":"Arvinas.2025. \u201cArvinas Presents First\u2010In\u2010Human Data for Investigational Oral PROTAC ARV\u2010102 Demonstrating Blood\u2010Brain Barrier Penetration and Central and Peripheral LRRK2 Degradation.\u201d [WWW Document]. 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