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Studies in rats indicate that abnormally high fetal brain KYNA may play a pathophysiologically significant role in this context (\u201cEKyn model\u201d). Here, we fed pregnant C57Bl\/6J mice with the immediate KYNA precursor kynurenine (10\u2009mg or 30\u2009mg\/day; EKyn) or with control chow (ECon) from embryonic day (ED) 11 to ED 18 and assessed offspring postnatally both functionally and biochemically. In adulthood, male, but not female, EKyn mice showed significant impairments in spatial and reversal learning. Moreover, ex\u00a0vivo recording of evoked local field potentials in coronal brain slices revealed a longer contralateral response latency in EKyn than in ECon animals, suggesting impaired white matter function. However, plasma and brain levels of KYNA and of another KP metabolite, 3\u2010hydroxykynurenine, did not differ between groups on postnatal day (PD) 21, on PD 35 (adolescence), or in adulthood (PD 56\u201375). Separate mice were fed prenatally with 4\u2010chloro\u2010kynurenine (20\u2009mg\/day), which is converted to the selective NMDA receptor antagonist 7\u2010chloro\u2010KYNA in\u00a0vivo. Offspring did not show electrophysiological impairments in adulthood, indicating that NMDA receptors in the fetal brain were not the sole cause of functional deficits of EKyn mice later in life. The implications of these experiments for the study of psychiatric symptoms, as well as the unexpected differences between rats and mice, are discussed.<\/jats:p>","DOI":"10.1111\/ejn.70185","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T02:39:19Z","timestamp":1752201559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Functional Impairments in Learning and Signal Propagation Following Prenatal Kynurenine Treatment in Mice"],"prefix":"10.1111","volume":"62","author":[{"given":"Sarah","family":"Beggiato","sequence":"first","affiliation":[{"name":"Department of Life Sciences and Biotechnology University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5778-3921","authenticated-orcid":false,"given":"P.\u00a0Leon","family":"Brown","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric 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