{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:37:50Z","timestamp":1792276670004,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The FK506 binding protein 51 (FKBP51) is a stress\u2010modulating protein implicated in stress\u2010related psychiatric disorders. While FKBP51 has been extensively studied in the brain and other tissues, its role in the adrenal gland, a key part of the stress response, remains unexplored. To investigate\n                    <jats:italic>Fkbp5<\/jats:italic>\n                    gene expression and FKBP51 function in the adrenal gland, we examined expression in C57Bl\/6 male and female mice and generated an adrenal cortex\u2010specific\n                    <jats:italic>Fkbp5<\/jats:italic>\n                    knockout (AS\n                    <jats:sup>\n                      <jats:italic>Fkbp5<\/jats:italic>\n                      \u2212\/\u2212\n                    <\/jats:sup>\n                    ). We found\n                    <jats:italic>Fkbp5<\/jats:italic>\n                    mRNA expression throughout the adrenal gland in both male and female mice. However, deletion of\n                    <jats:italic>Fkbp5<\/jats:italic>\n                    in the adrenal cortex did not alter basal stress hormone levels or acute restraint stress responses in both sexes and had no effect on chronic social defeat stress responses in male mice. These findings suggest that FKBP51 in the adrenal cortex plays another role than critically mediating acute or chronic social stress responses and highlight the potential for peripheral FKBP51 manipulations in the treatment of stress\u2010related disorders with no off\u2010target effects at the adrenal level.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70213","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:09:01Z","timestamp":1754453341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Glucocorticoid Receptor Co\u2010Chaperone FKBP51 in the Adrenal Cortex Is Not Involved in Regulating Hypothalamic\u2013Pituitary\u2013Adrenal Activity in the Mouse"],"prefix":"10.1111","volume":"62","author":[{"given":"London","family":"Aman","sequence":"first","affiliation":[{"name":"Research Group Neurobiology of Stress Resilience Max Planck Institute of Psychiatry  Munich 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