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Importantly, there may be an interaction between CB1r function and REM SD effects; however, evidence is sparse. In the present research, we investigated the interaction effect of REM SD and CB1r on anxiety, depressive\u2010like behavior, pain threshold, locomotor activity, and brain\u2010derived neurotrophic factor (BDNF) in rats. Arachidonylcyclopropylamide (ACPA; 1, 3, and 5\u2009ng\/side), a CB1r agonist, was injected intra\u2010CA1. REM SD was induced by the multiple platform apparatus for 48\u2009h. The results showed that 48\u2010h REM SD increased anxiety\u2010 and depressive\u2010like behaviors and decreased locomotion, pain threshold, and BDNF hippocampal level. ACPA dose\u2010dependently attenuated or restored these effects. ACPA (5\u2009ng\/side) also increased pain threshold in control and sham\u2010REM SD rats and decreased locomotion in sham\u2010REM SD rats. Pearson correlation test revealed that the more BDNF expression levels, the less feeding latency (anxiety\u2010like behavior) and the less immobility (depressive\u2010like behavior), meaning an indirect relationship (inverse relationship). By contrast, it showed that the more BDNF expression level, the more locomotor activity, the more pain threshold, and the more climbing, meaning a direct relationship. In conclusion, it can be suggested that CB1r activation in the CA1 region may interact with REM SD effects on behavioral functions and BDNF levels. For the first time, we showed that BDNF function in the CA1 region may modulate the effects of REM SD and CB1r activation on behavioral functions.<\/jats:p>","DOI":"10.1111\/ejn.70216","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:11:17Z","timestamp":1755076277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of CB1r Hippocampal Activation on Behavioral Changes and BDNF Levels in Rapid\u2010Eye Movement Sleep\u2010Deprived Rats"],"prefix":"10.1111","volume":"62","author":[{"given":"Paniz","family":"Azizi","sequence":"first","affiliation":[{"name":"Psychological and Brain Science Departments, Program in Neuroscience Indiana University  Bloomington Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anahita","family":"Najafi","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad\u2010Ali","family":"Samizadeh","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Lab, Medicinal Plants Research Center Institute of Medicinal Plants, ACECR  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Mohamadian","sequence":"additional","affiliation":[{"name":"Health Psychology Northcentral University San Diego  California USA"},{"name":"School of Behavioral Sciences California Southern University  Costa Mesa California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezu","family":"Jabbari","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Lab, Medicinal Plants Research Center Institute of Medicinal Plants, ACECR  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maede","family":"Rezaie","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, TeMS.C. Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-9887","authenticated-orcid":false,"given":"Salar","family":"Vaseghi","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center Institute of Medicinal Plants, ACECR  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-024-06566-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.704","article-title":"Nicotine\u2010Prevented Learning and Memory Impairment in REM Sleep\u2010Deprived Rat Is Modulated by DREAM Protein in the Hippocampus","volume":"7","author":"Abd Rashid N.","year":"2017","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.07.025"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12333"},{"key":"e_1_2_11_6_1","first-page":"20","article-title":"Effects of Rapid Eye Movement Sleep Deprivation on Pain Perception Level in Male Wistar Rats","volume":"1","author":"Ajao F.","year":"2011","journal-title":"Asian Journal of Biomedical and Pharmaceutical Sciences"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103656"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-024-01221-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311030001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00819-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.12.022"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2022.29.2.7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05149.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15040473"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1636-07.2007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13938"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.05.015"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00157-4"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0387-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5252"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03074.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.148039"},{"key":"e_1_2_11_23_1","first-page":"493","volume-title":"Handbook of Behavioral Neuroscience","author":"Carr G. 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