{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:56:54Z","timestamp":1785423414063,"version":"3.56.0"},"reference-count":84,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010NS127901"],"award-info":[{"award-number":["NIH\u2010NS127901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010NS126451"],"award-info":[{"award-number":["NIH\u2010NS126451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition. Recent brain imaging studies have highlighted the role of cortico\u2010striatal brain circuitry in pain chronification; however, the role of this circuitry in the persistence of CRPS pain has not been studied yet. Here, we investigated whether frequently reported changes in the cortico\u2010striatal brain circuitry in chronic pain extend also to chronic CRPS. CRPS patients were recruited as part of a research study on chronic pain. Quantitative sensory testing and resting\u2010state functional brain activity data were compared between 22 patients with acute CRPS (aCRPS, pain duration, &lt;\u200912\u2009months) and 20 with chronic CRPS (cCRPS, pain duration, &gt;\u200912\u2009months). Patients with cCRPS reported decreased sensitivity to pressure pain compared with aCRPS patients. In parallel, resting\u2010state brain activity power within the slow\u20105 low\u2010frequency band (0.01\u20130.027\u2009Hz) in the nucleus accumbens\u2014a brain functional signature identified in chronic low\u2010back pain patients\u2014was decreased in cCRPS patients and effectively discriminated acute from chronic CRPS patients, with an area under the curve (AUC) of 0.79. Although cortico\u2010striatal connectivity did not differ between the groups, exploratory whole\u2010brain comparisons revealed stronger connectivities in the aCRPS patients centered mainly on the precuneus\/posterior cingulate of the default mode network and the frontal operculum\/mid\u2010insula of the ventral attention\/salience network. These findings show that cCRPS patients share neuroplasticity in the accumbens with other chronic pain patients and suggest a major shift in functional connectivities affecting networks involved in nociceptive and self\u2010referential processing between aCRPS and cCRPS.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/\">https:\/\/drks.de\/<\/jats:ext-link>\n                    \u2010 registration number DRKS00016790\n                  <\/jats:p>","DOI":"10.1111\/ejn.70220","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:02:51Z","timestamp":1755075771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resting\u2010State Brain Activity in Acute and Chronic Complex Regional Pain Syndrome"],"prefix":"10.1111","volume":"62","author":[{"given":"Jiechu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neuroradiology University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Jammoul","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine and Dentistry University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kristin","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Centre for Interdisciplinary Pain Medicine University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain 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